Wako commercialized new inhibitors which were discovered by Dr. Hiroyuki Osada, Antibiotics laboratory of Institute of Physical and
Chemical Research (RIKEN) under license from RIKEN.
Nagumo, Y., Kakeya, H., Shoji, M., Hayashi, Y., Dohmae, N.
and Osada, H.: Biochem
. J.: 387
(3), 835 (2005).
Th is product is a derivative of epolactaene isolated from Penicillium. It has a
more potent cytostatic eff ect on human neuroblastoma cells SH-SY 5Y than that
of epolactaene, and induces apoptosis. Furthermore, it has been revealed that
ETB induces apoptosis in human T-lymphoma cells Jurkat. Recently, HSP60
was identifi ed as one of ETB binding proteins. ETB binds to HSP60 to inhibit
Protein Synthesis Inhibitor
Reveromycin A Sodium Salt
Woo, J. T., Kawatani, M., Kato, M., Shinki, T., Yonezawa, T.,
Kanoh, N., Nakagawa, H., Takami, M., Lee, K.H., Stern, P.H.,
Nagai, K. and Osada, H.: Proc. Natl. Acad.Sci. USA
Th is product is an antibiotic isolated from Streptomyces. It targets isoleucyl-tRNA
synthetase and inhibits protein synthesis in eukaryotes. It has been investigated for
its antitumor and antifungal activities. However, recent studies have revealed that
low-dose of reveromycin A induces cell death of activated osteoclasts, which leads
to acidic environment. Th us it receives attention as a candidate for the treatment of
osteoporosis/ multiple myeloma.
(Th is product is a sodium salt of the compound shown right.)
Mitsui, T., Miyake, Y., Kakeya, H., Hayasi, Y., Osada, H. and
Kataoka, T.: Biosci. Biotechnol. Biochem
Th is product is a derivative of epoxycylohexenone isolated from Paecilomyces. It
has lower toxicity than epoxycylohexenone. Like epoxycylohexenone, it inhibits
apoptosis not by inhibition of perforin-dependent pathway by cytotoxic T
lymphocytes but by selective inhibition of Fas ligand-dependent pathway alone.
Cell Cycle Inhibitor
Usui, T., Kondoh, M., Cui, C.B., Mayumi, T. and Osada, H.:
(3), 543 (1998).
Th is product is an alkaloid antibiotic isolated from Aspergillus. It aff ects the
microtubule-associated protein binding site and exhibits antitumor activity by
inhibition of cell cycle progression in the M phase specifi cally
||Wako Cat. No. (Pkg. Size)
||051-07671 (200 μL)
||Ship and keep at -20°C
|Protein Synthesis Inhibitor
||Reveromycin A Sodium Salt
||185-02181 (500 μg)
||182-02191 (200 μg)
|Cell Cycle Inhibitor
||203-16961 (500 μg)
Wako Product Update No.19 [ page. 3 ]