B. Cancer Research

1. Metastasis Suppressing Agent

Recent studies have shown that the expression of connexin 26, a protein component of gap junction, is increased in cancer cell lines, and suggested that the protein is involved in the mechanism of metastasis in cancer cells.
It has been revealed that MI-22 (metastasis inhibitor-22), which is a derivative of oleamide, does not only inhibit the connexin 26-mediated formation of gap junction between cancer and other cells but inhibits the spontaneous metastasis in vivo.
image
[Features]
1. Specific inhibition of connexin 26
2. Inhibition of gap junction intercellular communication
3. Inhibition of spontaneous metastasis in vivo
[References]
1. Ito, A., et al.,: J. Clin. Invest., 105, 1189 (2000).
2. Ito, A., et al.: Carcinogenesis, 25, 2015 (2004).
3. Ohba, Y., et al.: Int. J. Cancer, 121, 2801 (2007).
Description Wako Cat. No. (Pkg. Size) Note
MI-22 [Metastasis Inhibitor-22][N1,N1,N7,N7-Tetraethyl-2,6-di[(Z)-7-hexadecenyl]-heptanediamide]
C47H90N2O2 = 715.23
132-15043 (5 mg) Keep and Ship at 2~10 ˚C in a dark place.
Filled with inert gas.
Please arrange for immediate use after opening.
136-15041 (200 mg)

2. Alkylating Compounds

Description Wako Cat. No. (Pkg. Size) Target Cancer Note
1,4-Butanediol Dimethanesulfonate [Busulfan]
97.0+% (cGC), CAS No. 55-98-1, C6H14O6S2 = 246.30
029-09352 (25 g) Chronic myeloid leukemia Keep and ship below 25 ˚C in a dark place
Cyclophosphamide Monohydrate
97.0+% (Titration), CAS No. 6055-19-2,C7H15Cl2N2O2P•H2O = 279.10
030-12953 (1 g) Breast cancer, Ovary cancer, Malignant lymphoma Keep and ship at 2~10 ˚C in a dark place
034-12951 (5 g)
Dacarbazine 98.0+% (Potentiometric titration)
CAS No. 4342-03-4, C6H10N6O = 182.18
047-29951 (200 mg) Malignant melanoma, Malignant lymphoma Keep and ship at 2~10 ˚C in a dark place
043-29953 (1 g)
Ifosfamide 98.0+% (HPLC)
CAS No. 3778-73-2, C7H15Cl2N2O2P = 261.09
090-05401 (50 mg) Lung cancer, Prostate cancer Keep and ship below 25 ˚C in a dark place
096-05403 (500 mg)
Melphalan
CAS No. 148-82-3, C13H18Cl2N2O2 = 305.20
135-15251 (100 mg) Multiple myeloma Keep and ship below 25 ˚C in a dark place
131-15253 (1 g)
Procarbazine Hydrochloride
98.0+% (potentiometric titration)
CAS No. 366-70-1, C12H19N3O • HCl = 257.76
161-22581 (100 mg) Malignant lymphoma Keep and ship below 25 ˚C in a dark place
167-22583 (1 g)

3. Antimetabolic Drugs

Description Wako Cat. No. (Pkg. Size) Target Cancer Note
Carmofur
CAS No. 61422-45-5, C11H16FN3O3 = 257.26
035-20051 (1 g) Digestive organs cancer, Breast cancer Keep and ship at 2~10 ˚C in a dark place
031-20053 (5 g)
Cytosine-1-β-D(+)-arabinofuranoside [Cytarabine]
98.0+% (HPLC), CAS No. 147-94-4, C9H13N3O5 = 243.22
030-11951 (100 mg) Digestive organs cancer, Breast cancer, Acute myelogenous leukemia Keep and ship at 2~10 ˚C in a dark place
034-11954 (500 mg)
036-11953 (1 g)
Doxifluridine
CAS No. 3094-09-5, C9H11FN2O5 = 246.19
042-29901 (100 mg) Digestive organs cancer, Breast cancer Keep and ship below 25 ˚C in a dark place
048-29903 (1 g)
5-Fluorouracil [5-FU] 98.5+% (HPLC)
CAS No. 51-21-8, C4H3FN2O2 = 130.08
068-01401 (1 g) Breast cancer, Womb cancer, Digestive organs cancer Keep and ship at RT in a dark place
064-01403 (5 g)
066-01402 (25 g)
Hydroxyurea [Hydroxycarbamide] 90.0+% (Titration)
CAS No. 127-07-1, H2NCONHOH = 76.06
085-06653 (5 g) Chronic myeloid leukemia Keep and ship at 2~10 ˚C in a dark place
089-06651 (10 g)
6-Mercaptopurine Monohydrate 98.0~102.0%
CAS No. 6112-76-1, C5H4N4S • H2O = 170.19
130-07991 (1 g) Acute myelogenous leukemia, Chronic myeloid leukemia Keep and ship at RT in a dark place
136-07993 (5 g)
Methotrexate 98.0+% (HPLC)
CAS No. 59-05-2, C20H22N8O5 = 454.44
139-13571 (100 mg) Breast cancer, Chronic lymphoid leukemia Keep and ship at RT in a dark place
135-13573 (1 g)
1-(2-Tetrahydrofuryl)-5-fluorouracil [Tegafur]
98.0+% (Titration), CAS No. 17902-23-7, C8H9FN2O3 = 200.17
206-10351 (1 g) Digestive organs cancer, Breast cancer Keep and ship below 25 ˚C in a dark place
202-10353 ( 5 g)

4. Antibiotics

Description Wako Cat. No. (Pkg. Size) Target Cancer Note
Aclarubicin Hydrochloride Potency: 860+μg/mg
CAS No. 75443-99-1, C42H53NO15 • HCl = 843.34
017-12341 (10 mg) Digestive organs cancer, Breast cancer Keep at 2~10 ˚C in a dark place and ship at RT
Actinomycin D 97.0+% (HPLC)
CAS No. 50-76-0, C62H86N12O16 = 1255.42
013-13421 (5 mg) Wilms' tumor,Trophoblastic disease Keep and ship at -20 ˚C in a dark place
Bleomycin Hydrochloride Potency: 1,400~2,000μg/mg
CAS No. 67763-87-5, Molecular formula: Unspecified.
028-07801 (10 mg) Skin cancer,Head and neck cancer Keep at 2~10 ˚C in a dark place and ship at RT
Daunorubicin Hydrochloride
CAS No. 23541-50-6, C27H29NO10 • HCl = 563.98
043-30041 (5 mg) Acute leukemia Keep and ship at 2~10 ˚C in a dark place
049-30043 (50 mg)
Doxorubicin Hydrochloride [Adriamycin HCl]
Potency: 900+μg/mg
CAS No. 25316-40-9, C27H29NO11 • HCl = 579.98
040-21521 (10 mg) Digestive organs cancer, Malignant lymphoma Keep at 2~10 ˚C in a dark place and ship at RT
046-21523 (50 mg)
Epirubicin Hydrochloride
CAS No. 56390-09-1, C27H29NO11 • HCl = 579.98
058-07561 (1 mg) Malignant lymphoma, Digestive organs cancer Keep and ship at 2~10 ˚C in a dark place
054-07563 (5 mg)
Fumagillin
95+% (TLC), CAS No. 23110-15-8, C26H34O7 = 458.54
065-04071 (1 mg) Antiangiogenic Keep and ship at -20 ˚C in a dark place
061-04073 (5 mg)
Mitomycin C Potency: 850+μg/mg
CAS No. 50-07-7, C15H18N4O5 = 334.33
134-07911 (10 mg) Digestive organs cancer, Womb cancer Keep at 2~10 ˚C in a dark place and ship at RT
Mitomycin C with NaCl <Mitomycin: 2 mg; NaCl: 48 mg>
CAS No. 50-07-7, C15H18N4O5 = 334.33
132-13201 (2 mg)
138-13203 (2 mg x 10)
Peplomycin Sulfate Potency: 843+μg/mg
CAS No. 70384-29-1, C61H88N18O21S2 • H2SO4 = 1,571.68
169-12011 (10 mg) Skin cancer,Head and neck cancer Keep at 2~10 ˚C in a dark place and ship at RT
Pirarubicin Potency: 950+μg/mg
CAS No. 72496-41-4, C32H37NO12 = 627.64
160-14741 (25 mg) Breast cancer,Head and neck cancer Keep at 2~10 ˚C in a dark place and ship at RT

5. Plant Alkaloids

Description Wako Cat. No. (Pkg. Size) Target Cancer Note
Paclitaxel 97.0+% (HPLC)
CAS No. 33069-62-4, C47H51NO14 = 853.91
169-18616 (1 mg) Ovary cancer,
Stomach cancer,
Breast cancer,
Digestive organs cancer
Keep and ship at 2~10 ˚C in a dark place.
169-18611 (5 mg)
165-18613 (25 mg)
163-18614 (100 mg)
Vinblastine Sulfate 97.0+% (HPLC)
CAS No. 143-67-9, C46H58N4O9 • H2SO4 = 909.05
221-00751 (10 mg) Malignant lymphoma, Trophoblastic disease Keep and ship at 2~10 ˚C in a dark place.
227-00753 (50 mg)
Vindesine Sulfate 96.0+% (HPLC)
CAS No. 59917-39-4, C43H55N5O7 • H2SO4 = 852.00
225-01631 (2 mg) Lung cancer, Gullet cancer Keep and ship at -80 ˚C in a dark place.
221-01633 (10 mg)
Vinorelbine Ditartrate
CAS No. 125317-39-7, C45H54N4O8 • 2C4H6O6 = 1,079.11
222-01641 (10 mg) Lung cancer, Breast cancer Keep and ship at -20 ˚C in a dark place.Filled with inert gas
228-01643 (50 mg)

6. Synthetic Hormone Agents

Description Wako Cat. No. (Pkg. Size) Target Cancer Note
Cholormadinone Acetate 98.0+% (HPLC)
CAS No. 302-22-7, C23H29ClO4 = 404.93
035-15161 (1 g) Prostate dilation syndrome Keep and ship at RT in a dark place
031-15163 (5 g)
Dexamethasone 98.0~102.0% (Titration)
CAS No. 50-02-2, C22H29FO5 = 392.46
047-18863 (100 mg) Malignant lymphoma, Breast cancer Keep and ship at 2~10 ˚C in a dark place
041-18861 (1 g)
Flutamide 98.0+% (HPLC)
CAS No. 13311-84-7, C11H11F3N2O3 = 276.21
069-04851 (2 g) Prostate cancer Keep and ship below 25 ˚C in a dark place
065-04853 (10 g)
Medroxyprogesterone Acetate 98.0+% (HPLC)
CAS No. 71-58-9, C24H34O4 = 386.52
138-09991 (1 g) Breast cancer,Womb cancer Keep and ship at RT in a dark place
134-09993 (5 g)
Prednisolone 97.0~103.0% (Absorptiometry)
CAS No. 50-24-8, C21H28O5 = 360.45
165-11491 (1 g) Malignant lymphoma, Breast cancer Keep and ship at RT in a dark place
161-11493 (5 g)
Tamoxifen Citrate 98.0+% (Titration)
CAS No. 54965-24-1, C26H29NO • C6H8O7 = 563.64
209-14361 (250 mg) Breast cancer Keep and ship at 2~10 ˚C in a dark place.
205-14363 (1 g)
203-14364 (5 g)
207-14362 (25 g)

7. Platinum Complex

Description Wako Cat. No. (Pkg. Size) Target Cancer Note
Carboplatin 97.0+% (HPLC)
CAS No. 41575-94-4, C6H12N2O4Pt = 371.25
039-16041 (25 mg) Head and neck cancer, Lung cancer Keep and ship at RT in a dark place
035-16043 (250 mg)
Cisplatin 98.0+% (HPLC)
CAS No. 15663-27-1, PtCl2(NH3)2 = 300.05
033-20091 (200 mg) Bladder cancer,Head and neck cancer Keep and ship at 2~10 ˚C in a dark place. Filled with inert gas
039-20093 (2 g)
Oxaliplatin 97.0+% (HPLC)
CAS No. 61825-94-3, C8H14N2O4Pt = 397.29
156-02691 (5 mg) Colon cancer Keep and ship at -20 ˚C in a dark place
152-02693 (50 mg)

8. Immunostimulant

Description Wako Cat. No. (Pkg. Size) Target Cancer Note
Bestatin 96.0+% (HPLC)
C16H24N2O4 = 308.37
027-14101 (100 mg) nonspecific immunostimulant Keep and ship at -20 ˚C in a dark place

9. Others

Description Wako Cat. No. (Pkg. Size) Target Cancer Note
all-trans-Retinoic Acid [Tretinoin] 97.0+% (HPLC)
CAS No. 302-79-4, C20H28O2 = 300.44
186-01114 (50 mg) Acute myelogenous leukemia Keep and ship at -20 ˚C in a dark place
182-01116 (100 mg)
182-01111 (250 mg)
188-01113 (1 g)
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Wako Product Update No.19 [ page. 4-6 ]