E. Research for Signaling Cascade

Glutamate Receptor Substances

Ionotopic Receptors
  NMDA Selective
    NMDA Site >> DL-2-Amino-5-phosphonovaleric Acid, Dextromethorphan Hydrobromide Monohydrate, D-Glutamic Acid,
L-Glutamic Acid, DL-Glutamic Acid Monohydrate, (±)-Ibotenic Acid, N-Methyl-D-aspartic Acid
    Glycine Site >> D-Cycloserine, Glycine, D-Serine
    Polyamine Site >> Ifenprodil Tartrate, Spermidine, Spermine
    Ion Channel >> (+)-MK 801 Maleate
AMPA / Kainate Selective
    AMPA Selective >> AMPA, Joro Spider Toxin, Quisqualic Acid
    Kainate Selective >> Kainic Acid n-Hydrate
    AMPA / Kainate Selective >> CNQX disodium Salt , DNQX, NBQX
Metabotropic Receptors
DL-α-(3,5-Dihydroxyphenyl)glycine, (±)-Ibotenic Acid, (±)-α-Methyl-4-carboxyphenylglycine,
2-Methyl-6-(phenylethynyl)pyridine Hydrochloride

Alphabetically by product name

  Description Wako Cat. No. Note Grade
AMPA Selective
AMPA receptor agonist
(±)-α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic Acid [AMPA]
CAS No. 74341-63-2, C7H10N2O4=186.17
012-18491 (5mg) 2~10 ˚C for Biochemistry
NMDA Selective
NMDA receptor antagonist
DL-2-Amino-5-phosphonovaleric Acid [DL-AP5]
CAS No. 76326-31-3, C5H12NO5P=197.13
018-18471 (10mg) RT* for Biochemistry
AMPA/Kainate Selective
AMPA/Kainate receptor antagonist
CNQX Disodium Salt n-Hydrate, 98.0+% (HPLC)
C9H2N4Na2O4
034-20381 (10mg) 2~10 ˚C for Cellbiology
NMDA Selective
Glycine site agonist
D-Cycloserine
CAS No. 68-41-7, C3H6N2O2=102.09
032-12631 (1g)
038-12633 (5g)
-20 ˚C for Biochemistry
NMDA Selective
NMDA receptor antagonist
Dextromethorphan Hydrobromide Monohydrate, 98.0+% (Titration)
CAS No. 6700-34-1, C18H25NO • HBr • H2O=370.33
041-21551 (5g)
049-21552 (25g)
below 25 ˚C for Biochemistry
Metabotropic receptor
group1(mGlu1, mGlu5) agonist
DL-α-(3,5-Dihydroxyphenyl)glycine [DL-3,5-DHPG]
CAS No. 146255-66-5, C8H9NO4=183.16
043-24671 (100mg) Keep at 2~10 ˚C
Ship at RT
for Biochemistry
AMPA/Kainate Selective
AMPA/Kainate receptor antagonist
DNQX [6,7-Dinitroquinoxaline-2,3-dione], 95.0+% (
CAS No. 2379-57-9, C8H4N4O6=252.14
040-26303 (10mg)
044-26301 (50mg)
-20 ˚C for Biochemistry
NMDA Selective
NMDA receptor agonist
D-Glutamic Acid, 99.0+% (Titration)
CAS No. 6893-26-1, C5H9NO4=147.13
075-00493 (1g)
077-00492 (25g)
RT Wako Special Grade
L-Glutamic Acid, 99.0+% (Titration)
CAS No. 56-86-0, C5H9NO4=147.13
070-00502 (25g)
072-00501 (100g)
074-00505 (500g)
RT JIS Special Grade
DL-Glutamic Acid Monohydrate, 97.0+% (Titration)
CAS No. 19285-83-7, C6H9NO4 • H2O=165.15
074-02102 (25g) RT Wako Special Grade
NMDA Selective
Glycine site agonist
Glycine, 99.0+% (Titration)
CAS No. 56-40-6, H2NCH2COOH=75.07
073-00732 (25g)
075-00731 (100g)
077-00735 (500g)
RT JIS Special Grade
NMDA agonist
Metabotropic Receptor
Non-selective mGlu agonist
(±)-Ibotenic Acid
CAS No. 2552-55-8, C5H6N2O4=158.11
098-04721 (5mg) RT for Biochemistry
NMDA Selective
Polyamine Site
Ifenprodil Tartrate, 98.5+% (Titration)
CAS No. 23210-58-4, (C21H27NO2)2 • C4H6O6=800.98
099-03911 (100mg) RT for Biochemistry
AMPA Selective
AMPA receptor antagonist
Joro Spider Toxin [JSTX-3]
CAS No. 112163-33-4, C27H47N7O6=565.71
104-00051 (0.1mg) 2~10 ˚C for Biochemistry
Kainate Selective
Kainate receptor agonist
Kainic Acid n-Hydrate, 98.0+% (HPLC)
C10H15NO4 • nH2O=213.23


It is an amino acid with glutamate skeleton isolated from one of red algae, Digenea (Corsican weed, Digenea simplex) known as an ascaricide.
This product is one of selective agonist for kainate-type glutamate receptor and has a potent CNS stimulating effect. It is used for studies on the signal transduction system via kainate cascade, neuronal apoptosis, ALS (amyotrophic lateral sclerosis), and pathological mechanism of Alzheimer disease.
Appearance of solution: Clear
118-00751 (10mg) 2~10 ˚C for Biochemistry
Metabotropic Receptor
group1(mGlu1, mGlu5), group2(mGlu2, mGlu3) antagonist
(±)-MCPG
[(±)-α-Methyl-4-carboxyphenylglycine]
99.0+% (HPLC)
CAS No. 146669-29-6; C10H11NO4=209.20

137-15571 (10mg)
133-15573 (50mg)
2~10 ˚C for Cellbiology
NMDA Selective
ion channel
Non-competitive NMDA receptor antagonist
(+)-MK 801 Maleate [Dizocilpine Maleate], 98.0+% (HPLC)
CAS No. 77086-22-7; C16H15N.C4H4O4=337.37
Acts by binding to a site located within the NMDA associated ion channel

It is a noncompetitive antagonist showing selectivity for NMDA-type glutamate receptor. It binds to the pore of the ion channel, which is opened by the binding of ligands, and acts as an open-channel blocker
134-15461 (10mg)
130-15463 (50mg)
2~10 ˚C for Cellbiology
Metabotropic Receptor
Metabotropic receptor mGlu5
Non-competitive antagonist at mGlu5 receptor subtype
MPEP Hydrochloride, 98.0+% (HPLC)
[2-Methyl-6-(phenylethynyl)pyridine Hydrochloride],
C14H11N.HCl=229.70

It is a potent noncompetitive antagonist showing selectivity for metabotropic glutamate receptor 5 (mGluR5).
131-15471 (10mg) 2~10 ˚C for Cellbiology
AMPA/Kainate Selective
AMPA/Kainate receptor antagonist
NBQX [6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione], 99+% (TLC)
CAS No. 118876-58-7, C12H8N4O6S=336.28
148-06751 (10mg) 2~10 ˚C for Biochemistry
NMDA Selective
NMDA receptor agonist
N-Methyl-D-aspartic Acid [NMDA]
CAS No. 6384-92-5, C5H9NO4=147.13
132-13681 (50mg) RT for Biochemistry
NMDA Selective
Glycine site agonist
D-Serine, 99.0+% (Titration)
CAS No. 312-84-5, HOCH2CH(NH2)COOH
191-08821 (1g)
197-08823 (5g)
199-08822 (25g)
RT Wako Special Grade
AMPA Selective
Metabotropic Receptor
Group1 (mGlu1, mGlu5) agonist
Quisqualic Acid
CAS No. 52809-07-1, C5H7N3O5=189.13
174-00531 (5mg) 2~10 ˚C for Biochemistry
NMDA Selective
Polyamine site agonist
Spermidine, 95.0+% (Titration)
CAS No. 124-20-9, H2N(CH2)4NH(CH2)3NH2=145.25
195-09821 (1g)
191-09823 (5g)
2~10 ˚C for Biochemistry
NMDA Selective
Polyamine site
Spermine, 95.0+% (Titration)
CAS No. 71-44-3, C10H26N4=202.34

Acts as an agonist during depolarization and as an antagonist during hyperpolarization.
198-09811 (250mg)
194-09813 (1g)
2~10 ˚C for Biochemistry
* RT: room temperature
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Wako Product Update No.19 [ page. 8-9 ]