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8. Physiological Active Substances

Carbenicillin Sodium Salt
Wako Cat. No. 032-18954 (1 g); 038-18951 (5 g); 034-18953 (10 g) < for Cellbiology>
Wako Cat. No. 030-17671 (1 g); 036-17673 (5 g); 034-17674 (10 g) < for Biochemistry>
Keep at 2~10℃

Penicillin antibiotic acting on Gram-negative bacteria; bacterial cell-wall synthesis inhibitor

[both for Biochemistry and for Cellbiology]

Appearance:White ~ slightly greenish yellow, crystalline powder ~ powder
Potency:770+ ug/mg (calculated on the dried basis)
Solubility: Soluble in water (0.5 g/50 mL)
Wako Cat. No. 032-19451 (5 g); 030-19452 (25 g); 038-19453 (100 g) <for Molecular Biology, DNase and RNase tested>
Wako Cat. No. 036-10571 (5 g); 034-10572 (25 g); 032-10573 (100 g) <for Biochemistry>
Wako Cat. No. 037-19641 (200 mg) < 98.0+ % (HPLC), Standard for HPLC>
Keep at 2~10℃

The product inhibits protein synthesis in bacteria thus suppressing their proliferation (bacteriostatic effect). It exhibits a strong activity especially against Gram-negative bacilli such as Salmonellae and rickettsia such as epidemic louse-borne typhus and chigger.
This is an analogue of nitrobenzene. Although it has a wide antimicrobial spectrum, it is used only in cases where other antibiotics are ineffective or in critical conditions due to its strong adverse reactions.
Appearance:White ~ slightly yellow, crystals ~ crystalline powder
Solubility:Freely soluble in methanol and ethanol.
Slightly soluble in water and ether.
Ciclosporin A, 97.0+ % (HPLC)
Wako Cat. No. 035-16303 (100 mg); 039-16301 (200 mg) <for Biochemistry >
Wako Cat. No. 031-18963 (50 mg); 035-18961 (200 mg) <for Cellbiology >
Keep at 2~10℃

<Pharmacologic and Physiologic Research><Autacoid>
Like hormones, autacoids exhibit strong bioactivity in small amounts, but unlike hormones they have no particular production organ, and they refer to biologically active substances expressing strong physiological effects immediately at the site of production. Chemically, they are classifi ed into amines (such as histamine and serotonin), peptides (such as bradykinin and angiotensin) and fatty acids (such as prostaglandin).
The product is a typical immunosuppressant used for prevention of graft rejection after organ transplantation. It is a cyclic polypeptide consisting of 11 amino acids and inhibits secretion of interleukin 2 from helper T cells, which promote immune reaction, and thus inhibits immunity.
Appearance: White, crystalline powder ~ powder or mass
Solubility: Very soluble in methanol and ethanol.
Freely soluble in acetone and ether. Practically insoluble in water.
Vacuolar H+-ATPase Inhibitor
Concanamycin A,90.0+ % (HPLC)
Wako Cat. No. 036-16034 (25 µg); 032-16031 (100 µg) <for Biochemistry>
Keep at -20℃

Concanamycin A is a specifi c inhibitor of V-ATPases. Isolated from an antifungal biotic of the 18-membered macrocyclic lactones,
Concanamycin A inhibits blastogenesis of cultured cells stimulated by Concanavalin A (Con-A). While Concanamycin A is structurally and pharmacologically similar to Bafi lomycin A1. It exhibits about 10 times stronger inhibition than that by Bafi lomycin A1.
Appearance::White, crystals ~ powder
Solubility: Freely soluble in chloroform, methanol, ethanol, acetone, ethyl acetate and DMSO.
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Wako Product Update Bio-No.1 [ page. 27 ]