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8. Physiological Active Substances

Neurotoxin - Glutamate Receptor Selective Agonist
Joro Spider Toxin [JSTX-3], 98.0+ % (HPLC)
Wako Cat. No. 104-00051 (0.1 mg) <for Biochemistry>
Keep at 2~10℃

JSTX-3 is derived from the venom of Nephila clavata and consist of three active principles of similar chemical structure and function. Each of these components has been found to be a potent antagonist of neurotransmitter receptors. Wako offers JSTX-3, a chemical of low molecular weight which selectively inhibits excitatory synaptic transmission by blocking quisqualate-sensitive L-glutamate receptors. The high degree of specifi city JSTX-3 exhibits makes it an especially valuable tool for the study of neurological disorders and for the research of excitatory neurotransmitter mechanisms.

Solubility:Soluble in water

Neurotoxin - Glutamate Receptor Selective Agonist
Kainic Acid n-Hydrate, 98.0+ % (HPLC)
Wako Cat. No. 118-00751 (10 mg) <for Biochemistry>
Keep at 2~10℃

GGsTop™ is a highly selective γ-Glutamyl Transpeptidase (GGT) It is an amino acid with glutamate skeleton isolated from a red algae, Digenea (Corsican weed, Digenea simplex) known as an ascaricide. This product is one of selective agonist for kainate-type glutamate receptor and has a potent CNS stimulating effet. It is used for studies on the signal transduction system via kainate cascade, neuronal apoptosis, ALS (amyotrophic lateral sclerosis), and pathological mechanism of Alzheimer's disease.
Potent Synthesis Inhibitor - Aminoglycoside Antibiotic
Kanamycin Sulfate
Wako Cat. No. 117-00341 (1 g); 113-00343 (5 g); 115-00342 (25 g); 111-00344 (100 g) <for Biochemistry>
Wako Cat. No. 113-00701 (1 g); 119-00703 (5 g); 117-00704 (100 g) <for Cell Culture>
Keep at 2~10℃

Appearance: White ~ slightly pale yellow, crystals ~ powder or mass
Potency: 600+ ug/mg (calculated on the dried basis)
Solubility: Freely soluble in water. Practically insoluble in ethanol and ether.
Neurotoxin - NMDA-Glutamate Receptor Antagonist
(+)-MK 801 Maleate [Dizocilpine Maleate], 98.0+ % (HPLC)
Wako Cat. No. 134-15461 (10 mg); 130-15463 (50 mg) <for Cellbiology>
Keep at 2~10℃

Acts by binding to a site located within the NMDA associated ion channel.
It is a non-competitive antagonist showing selectivity for NMDA-type glutamate receptor.
It binds to the pore of the ion channel, which is opened by the binding of ligands, and acts as an open-channel blocker.
Appearance: White ~ nearly white, crystals ~ powder
Marine Toxin - Actin Inhibitor
Mycalolide B, 98.0+ % (HPLC)
Wako Cat. No. 132-12081 (100 µg) <for Biochemistry>
Keep at -20℃

Inhibits actin polymerization. Mycalolide B depolymerizes F-actin by nibbling and forms a 1:1 complex with G-actin.
Source: Mycale sp.
Appearance: Clear fi lm
Solubility: Soluble in methanol, ethanol and DMSO.
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Wako Product Update Bio-No.1 [ page. 30 ]