8. Physiological Active Substances

Polymethoxy Flavonoids derived from Shekwasha
Nobiletin, 95.0+ % (HPLC)
Wako Cat. No. 149-07521 (10 mg) <for Biochemistry>
Tangeretin, 95.0+ % (HPLC)
Wako Cat. No. 208-15671 (10 mg) <for Biochemistry>
Keep at -20℃


Nobiletin and tangeretin are polymethoxy fl avonoids contained in the juice of Shekwasha (Citrus depressa Hayata), a citrus fruit. These fl avonoids are receiving attention for a variety of benefi cial effects such as reducing elevation of blood pressure and plasma glucose levels.
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[Nobiletin]
Appearance: White ~ slightly pale yellow, crystalline powder ~ powder or mass
Solubility: Soluble in ethanol, methanol and acetone.
[Tangeretin]
Appearance: White ~ nearly white, crystalline powder ~ powder
Solubility: Soluble in ethanol and methanol. Insoluble in water.
[References]
1) Rooprai, H. K. et al.: "Evaluation of the eff ects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro", Neuropathol.Appl.
Neurobiol., 27, 29 (2001)
2) Datla, K. P. et al.: "Tissue distribution and neuroprotective eff ects of citrus fl avonoid tangeretin in a rat model of Parkinson's disease", Neuroreport, 12, 3871 (2001)

Protein phosphatase inhibitor
Okadaic Acid
[Okadaic Acid] Wako Cat. No. 150-01653 (25 µg); 154-01651 (100 µg) <for Biochemistry>
[Ammonium Salt] Wako Cat. No. 156-02211 (100 µg); 152-02213 (500 µg) <for Biochemistry>
Keep at 2~10℃
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Okadaic acid is a causative agent of diarrhetic shellfi sh poisoning and a potent and specifi c inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A) that is isolated from the sponge Halichondria Okadai.

Appearance: [Okadaic Acid] Lyophilized, fi lm; [Ammonium Salt] Lyophilized
Assay (HPLC): [Okadaic Acid] 80.0+%
Solubility: [Okadaic Acid] Soluble in DMF, DMSO, Chloroform-methanol.
Slightly soluble in water and n-hexane.
[Ammonium Salt] 100ug/100uL (water)
[References]
1) Tachibana, K. et al.: J. Am. Chem. Soc., 103, 2469-71 (1981)
2) Suganuma, M. et al., "Okadaic acid: an additional non-phorbol-12-tetradecanoate-13- acetate-type tumor promoter", Proc. Natl. Acad. Sci. USA, 85, 1768-71 (1988)
3) Ozaki, H. et al.: "Calcium-independent phosphorylation of smooth muscle myosin light chain by okadaic acid isolated from black sponge (Halichondria okadai).", J. Pharmacol. Exp. Ther., 243, 1167-73 (1987)
Neurotoxin; Na+ Channel Agonist
Palytoxin, 90.0+ % (HPLC)
Wako Cat. No. 161-15131 (100 µg) <for Biochemistry>
Keep at 2~10℃

Palytoxin is a potent marine toxin which acts as a strong hemolysin, histamine releaser, inhibitor of sodium-potassium ATPase, and cation ionophore.
Appearance: Film (invisible due to very small quantity)
Solubility: Soluble in pyridine, DMSO and water. Slightly soluble in ethanol and methanol. Insoluble in chloroform, ether and acetone.
[References]
1) Uemura, D., Hirata, Y., Iwashita, T. and Naoki, H.: Tetrahedron, 41, 1007 (1985).
2) Cha, J.K., Christ, W.J., Finan, J.M., Fujioka, H., Kishi, Y., Klein, L., Ko, S.S., Leder J., McWhater, W.W., Jr. Pfaff . K.-P., Yonaga, M., Uemura, D. and Hirata, Y.: J. Am. Chem. Soc., 104, 7369 (1982).
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Wako Product Update Bio-No.1 [ page. 31 ]