8. Physiological Active Substances

Calmodulin Inhibitor
Stellettamide A Trifl uoroacetate, 95.0+ % (HPLC)
Wako Cat. No. 193-11831 (100 µg) <for Biochemistry>
Keep at -20℃, Lyophilized

Stellettamide A (ST-A) is a marine toxin isolated from a marine sponge.
It is a calmodulin antagonist and inhibits Ca2+-calmodulin-dependent phosphodiesterase.

Source: Stelletta sponge
Solubility: Soluble in methanol (100 ug/100 uL)
Abe, Y., et al.: "Stellettamide-A, a novel inhibitor of calmodulin, isolated from a marine sponge", Br. J. Pharmacol., 121, 1309 (1997)
Protein Phosphatase Inhibitor
Wako Cat. No. 209-12041 (100 µg) <for Biochemistry>
Keep at -20℃, Lyophilized

Tautomycin, is a highly potent and specifi c protein phosphatase inhibitor, induced morphological change (bleb-formation) of human myeloid leukemia K562 cells.
The appearance of blebs is inhibited by protein kinase C (PKC) inhibitors.
Tautomycin acts as an activator of PKC.

Source: Streotomyces spiroverticillatus
Solubility: Soluble in ethanol. Practically insoluble in water.

1) Hori, M., Magae, J., Han, Y-G., Hartshorne, D.J. and Karaki, H.:"A novel protein phosphatase inhibitor, tautomycin Eff ect on smooth muscle", FEBS LETTERS, 285, 145 (1991)
2) Magae, J., Osada, H., Fujiki, H.,Saido, T., Suzuki, K., Nagai, K., Yamasaki, M. and Isono, K.: "Morphological changes of human myeloid leukemia K-562 cells by a protein phosphatase inhibitor, tautomycin", Proc. Jpn. Acad., 66(B), 209-12 (1990)
3) Kurisaki, T., et al.: "Morphological changes and reorganization of actinfi laments in human myeloid leukemia cells induced by a novel protein phosphatase inhibitor, tautomycin", Cell Struct. Funct., 18, 33-9 (1993)
4) Ubukata, M. et al.: J. Chem. Soc. Chem. Commun., 244 (1991)
5) Ubukata, M. et al.: J. Chem. Soc. Perkin Trans., 1, 617 (1993).
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Wako Product Update Bio-No.1 [ page. 34 ]