2. Antibodies

2-b) Antibodies useful for diabetes mellitus -manufactured by TransGenic-

TRANS GENIC INC
Antibody useful for research in diabetes mellitus

The products of the nonenzymatic glycation and oxidation of proteins, lipids and nucleic acids, the advanced glycation end-products (AGEs), accumulate in various pathological conditions, such as diabetes, infl ammation, renal failure, and aging. AGEs can arise not only from glucose, but also from dicarbonyl compounds, short chain-reducing sugars and other metabolic pathways of glucose. Several AGEs have been already identifi ed including AGE-1 ~ 6, CML, CEL. Recently studies demonstrated that the presence of AGEs-modifi ed proteins in several human tissues: (ⅰ) human lens (nondiabetic and noncataractous), (ⅱ) renal proximal tubules in patients with diabetic nephropathy and chronic renal failure, (ⅲ) diabetic retina, (ⅳ) peripheral nerves of diabetic neuropathy, (ⅴ) atherosclerotic lesions of arterial walls, (ⅵ) b2-microglobulin forming amyloid fi brils in patients with hemodialysis-related amyloidosis, (ⅶ) senile plaques of patients with Alzheimer's disease, (ⅷ) the peritoneum of CAPD patients, (ⅸ) skin elastin in actinic elastosis, and (ⅹ) ceriod/lipofuscin deposits, suggesting that AGEs are deeply involved in diabetes and complications of diabetes mellitus.


Immnohistochemical staining of renal proximal fubules and glomeruli in patients with diabetic nephropathy,using anti-AGEs antibody 6D12.
Yamada, K. et al. : Clinical Nephrology, 42, 354-361,1994.
 
Immnohistochemical staining of the eary stage of human athrosclerotic lesions of the aorta with anti -AGEs anitibody 6D12.
Kume,S, et al.: American Journal of Pathology, 147, 654-667, 1995.

Western blotting
with anti AGE-3 antibody
(Clone No.9 D8)
1: AGE1-BSA (glucose-modified)
2: AGE2-BSA (glyceraldehyde -modified)
3: AGE3-BSA (glycolaldehyde -modified)
4: AGE4-BSA (methylglyoxal -modified)
5: AGE5-BSA (glyoxal-modified)
6: AGE6-BSA (3-DG-modified)
7: CKL-BSA (carboxymethyllysine -modified)
8: CEL-BSA (carboxyethyllysine -modified)
9: BSA

Trans Genic homepage: http://www.transgenic.co.jp

TRANS GENIC INC
List of antibody useful for research in diabetes mellitus (for Research Use Only)

Wako Cat. No.
Product Name
Pkg. Size
Specificity
306-08731
Anti AGEs, Monoclonal Antibody (Clone: 6D12)
[KH001]
10 μg /40 μL
every animal species
308-34941
Anti AGEs Monoclonal Antibody ( Clone No. 6D12 ), Biotin conjugated
[KH001-01]
10 μg /40 μL
every animal species
302-35941
Anti AGEs Monoclonal Antibody (Clone No.6D12), Peroxidase Conjugated
[KH001-02]
20 μg /200 μL
every animal species
305-08821
Anti Pyrraline Monoclonal Antibody (Clone No.H12)
[KH010]
20 μg /80 μL
every animal species
305-34951
Anti Pyrraline Monoclonal Antibody ( Clone No. H12 ), Biotin conjugated
[KH010-01]
20 μg /80 μL
every animal species
302-34961
Anti Pyrraline Monoclonal Antibody ( Clone No. H12 ), Peroxidase conjugated
[KH010-02]
20 μg /80 μL
every animal species
302-08831
Anti CML Monoclonal Antibody(Clone No.CMS-10)
[KH001]
50 μg /200 μL
every animal species
309-34971
Anti CML Monoclonal Antibody (Clone No. CMS-10 ), Biotin conjugated
[KH011-01]
50 μg /200 μL
every animal species
306-34981
Anti CML Monoclonal Antibody (Clone No. CMS-10 ), Peroxidase conjugated
[KH011-02]
50 μg /200 μL
every animal species
309-08841
Anti Pentosidine Monoclonal Antibody (Clone No. PEN-12 )*
[KH012]
50 μg /200 μL
every animal species
303-34991
Anti Pentosidine Monoclonal Antibody (Clone No. PEN-12 ), Biotin conjugated*
[KH012-01]
50 μg /200 μL
every animal species
300-35001
Anti Pentosidine Monoclonal Antibody ( Clone No. PEN-12 ), Peroxidase conjugated*
[KH012-02]
50 μg /200 μL
every animal species
303-09961
Anti CML Monoclonal Antibody (Clone No. NF-1G )
[KH024]
50 μg /200 μL
every animal species
307-09981
Anti CML Monoclonal Antibody (Clone No. NF-1G ), Biotin conjugated
[KH024-01]
50 μg /200 μL
every animal species
304-09991
Anti CML Monoclonal Antibody (Clone No. NF-1G ), Peroxidase conjugated
[KH024-02]
50 μg /200 μL
every animal species
300-09971
Anti CEL Monoclonal Antibody (Clone No. KNH-30 )
[KH025]
50 μg /200 μL
every animal species
305-10031
Anti CEL, Monoclonal Antibody (Clone: KNH-30), Biotin Conjugated
[KH025-01]
50 μg /200 μL
every animal species
302-10041
Anti CEL, Monoclonal Antibody (Clone: KNH-30), Peroxidase conjugated
[KH025-02]
50 μg /200 μL
every animal species
304-13041
Anti Human RAGE polyclonal Antibody, Rabbit
[KH039]
100 μg /400 μL
Human
308-10381
Anti Human Galectin-3 polyclonal Antibody, Rabbit
[KH040]
100 μg /400 μL
Human
305-13451
Anti 3-DG-imidazolone Monoclonal Antibody (Clone No. JNH-27)
[KH043]
50 μg /200 μL
every animal species
308-31881
Anti Human PPARr Polyclonal Antibody
[KG113]
100 μg /400 μL
Human
305-31891
Anti Human AdipoR1 Polyclonal Antibody
[KG114]
100 μg /400 μL
Human
308-31901
Anti Human B3-AR Polyclonal Antibody
[KG115]
100 μg /400 μL
Human
309-34111
Anti AGE-3 Monoclonal Antibody (Clone No. 9D8)
[KG122]
10 μg /40 μL
every animal species
307-34891
Anti AGE-1 Monoclonal Antibody ( Clone No. 7C1 )
[KG132]
10 μg /40 μL
every animal species
300-34901
Anti AGE-4 Monoclonal Antibody ( Clone No. 14B5 )
[KG133]
10 μg /40 μL
every animal species
307-34911
Anti Human RAGE Monoclonal Antibody (Clone No. 1C5)
[KG134]
50 μg /200 μL
Human
302-34601
AGEs-BSA**
[KH001-A]
1mg/mL
-
[ ]: TransGenic Product No.
* Not available for sale in USA.
**Antigen
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