3. Reagents for Diabetes Research

3-g) Others

Acrp30, globular domain, Mouse, recombinant [Acrp30 : substance which improves insulin resistance]

Wako Cat. #017-19541 (25 μg)
Keep at -20C, Lyophilized

Acrp30 is a mouse homologue of adiponectin1). Adiponectin/Acrp30 is a adipocytokine secreted by adipose tissues. Unlike TNF-a or leptin, the serum levels of Acrp30 is known to decrease as obesity increases. It was recently reported that injection of adiponectin to diabetic mice improved insulin resistance2).
Mouse globular domain is a decomposition product of Acrp30 with molecular weight of 16,000 comprising 145 amino acids3).
It is characterized by more potent activity than Acrp30.
Appearance : Lyophilized from the fi lter sterilized 5 mmol/L Tris (pH 7.6)
Source : Mouse globular domain Acrp30- cDNA expressed in E. coli.
Endotoxin : < 0.1 ng/μg (1 Eμ/μg)
Reconstitution : Dissolve with 5 mmol/L Tris (pH 7.6) to make 0.1~1.0 mg/mL solution.

1) Maeda, K. et al.: "cDNA cloning and expression of a novel adipose specifi c collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).", Biochem. Biophys. Res. Commun., 221, 286-9 (1996).
2) Yamauchi, T. et al.: "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity", Nat. Med., 7, 941-6 (2001).
3) Scherer, P.E., et al.: "A novel serum protein similar to C1q, produced exclusively in adipocytes", J. Biol. Chem., 270, 24746-9 (1995).

Description Wako Cat. # (Pkg. Size) Note
Sorbitol Dehydrogenase 199-12391 (500 units) Research for Diabetes Complication
Acrp30, Globular Domain, Mouse, recombinant
(Acrp30: 30-kDa adipocyte complement-related prtein)
017-19541 ( 25 μg)mouse homologue of adiponectin
Betacellulin, Rat, recombinant022-14391 ( 10 μg)a member of the epidermal growth factor family
Betacellulin, Human, recombinant 025-14381 ( 10 μg)
Dendrotoxin I [4330-s]339-43301 ( 0.1 mg vial)Voltage-Dependent K+ Channel Blocker
Hypericin 086-07761 ( 1 mg)Inhibits protein kinase C, insulin receptor, EGF receptor, casein kinase II, and thyrosine kinase activity of MAP kinase.
082-07763 ( 5 mg)
D-chiro-Inositol 090-03821 (100 mg)for research on non-insulin-dependent diabetes
096-03823 (500 mg)
Insulin, Human, recombinant 090-03446 (50 mg)Source: Yeast expressed human insulin
096-03443 (100 mg)
090-03441 ( 1 g)
094-03444 ( 10 g)
Insulin-like Growth Factor-I (IGF-I), Human, recombinant 099-04511 (100 μg)Related to promotion of glucose uptake and oxidation in fat tissue and muscle (insulin-like action) and promotion of DNA synthesis in fi broblasts
Insulin-like Growth Factor-II (IGF-II), Human, recombinant 092-04523 ( 50 μg)
Karanjin114-00471 (500 mg)antihyperglycemic agent
Margatoxin [4290-s]331-42901 ( 0.1 mg vial)Voltage-Dependent K+ Channel Blocker (Specifi c for Kv1.3 Channel )
MCD-Peptide [4258-v]333-42581 ( 0.5 mg vial)Voltage-Dependent K+ Channel Blocker
Stichodactyla Toxin [4287-s]334-42871 ( 0.1 mg vial)Voltage-Dependent K+ Channel (A Channel) Blocker
Streptozotocin (STZ)549-00281 (100 mg)Preparation of Experimental Diabetes Model / streptozotocin, an antibiotic and diabetogenic nitrosamine compound derived from Streptomyces achromogenes to induce new kidney tumors in BALB/c mice.
549-00286 ( 5 g)
Tityustoxin Ka [4313-s]338-43131 ( 0.1 mg vial)Voltage-Dependent K+ Channel (A Channel) Blocker
        [  ]: Peptide Institute Product No.
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