4. Reagents for Hyperlipidemia Research

4-a) HMG-CoA Reductase Inhibitors

Competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase are the rate limiting enzymes in cholesterol biosynthesis. By blocking the conversion of HMG-CoA to the cholesterol precursor mevalonate, these agents inhibit hepatic synthesis of cholesterol, causing a subsequent stimulation of LDL receptors and an increase in the clearance of LDL and its precursor particles from the circulation.

[References]
1) Singer, I. I., et al.: "Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes", Proc. Natl. Acad. Sci. USA, 85, 5264-8 (1988).
2) Endo, A., et al.: "Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity", FEBS LETTERS, 72, 323-6 (1976).
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Description Wako Cat. # (Pkg. Size) Note
Compactin [ML-236B], 95+% (HPLC) 033-17301 (25 mg) MW: 390.51 (C23H34O5), CAS: 73573-88-3, Keep at 2~10°C
Lovastatin, 95+% (HPLC) * 125-04581 (25 mg) MW: 404.55 (C24H36O5), CAS: 75330-75-5, Keep at 2~10°C
Pravastatin Sodium Salt, 95+% (HPLC) 162-19821 (25 mg)
168-19823 (100 mg)
MW: 446.51 (C23H35NaO7), CAS: 81131-70-6, Keep at 2~10°C
Simvastatin, 95+% (HPLC) 193-12051 (25 mg)
199-12053 (100 mg)
MW: 418.57 (C25H38O5), CAS: 79902-63-9, Keep at 2~10°C

*: Not available for sale in USA.

4-b) Triglyceride Biosynthesis Inhibitor

Description Wako Cat. # (Pkg. Size) Note
Clofibrate, 98.0+% (cGC) 039-10603 ( 25 mL) MW: 242.70, CAS: 637-07-0, Keep at 2~10°C
Bezafibrate, 97.0+% 022-16091 ( 5 g)
028-16093 (100 g)
MW: 361.82 (C19H20ClNO4), CAS: 41859-67-0, Keep at a cool place

4-c) Cholesterol Catabolism Enhancer

Description Wako Cat. # (Pkg. Size) Note
Probucol, 97.0+% (HPLC) 162-20311 ( 1 g)
166-20314 ( 5 g)
168-20313 (10 g)
4, 4'-Isopropylidenedithio-bis (2,6-di-tert-butyl-phenol) C31H48O2S2: 516.84, CAS: 23288-49-5, Keep at RT

4-d) Cholesterol Absorption Inhibitors

Description Wako Cat. # (Pkg. Size) Note
β-Sitosterol, 97+% (GC) 309-01401 (100 mg) MW: 414.72 (C29H50O), CAS: 83-46-5, Keep at 2~10°C

4-e) LPL Activators

Description Wako Cat. # (Pkg. Size) Note
Sodium Dextran Sulfate 5,000, for Biochemistry 197-08362 ( 25 g)
199-08361 (100 g)
191-08365 (500 g)
Lipoprotein Lipase (LPL) activator. Keep at RT
Sodium Dextran Sulfate 5000, for Molecular Biology 194-13402 ( 25 g)
196-13401 (100 g)
198-13405 (500 g)
Lipoprotein Lipase (LPL) activator / nucleic acid hybridization accelerator/ DNase and RNase activity are tested on each lot. For molecular biology. Keep at RT.
Sodium Dextran Sulfate 36,000-50,000 194-14921 ( 10 g)
190-14923 (100 g)
196-14925 (500 g)
Lipoprotein Lipase (LPL) activator. Keep at 2~10°C
Sodium Dextran Sulfate 500,000 193-09981 ( 10 g)
199-09983 ( 50 g)
197-09984 (100 g)

4-f) Others

Description Wako Cat. # (Pkg. Size) Note
L-Aminocarnitine 018-15291 (10 mg) Fatty Fatty Acid Metabolic Inhibitor. Keep at 2~10°C
Phosphoinositide 3-Kinase p110γ,Human, recombinant 168-20531 (10 μg) Keep at -20°C
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Wako Product Update Bio-No.2 [ page. 21,22 ]