Wako Pure Chemical Industries, Ltd.Wako Pure Chemical Industries, Ltd. - Laboratory Chemicals
Home > Products > Chemicas > Material Chemistry > FMTS

De Novo Monofluoromethylating Agent
Fluoromethyl p-Toluenesulfonate (FMTS)



This is a reagent that separately monofluoromethylates alcohols, thiols, amines, etc. It can contribute to development of candidate pharmaceutical compounds with the monofluoromethyl group.





1. Features



  • Stable to both air and moisture and storable at room temperature
  • Under mild conditions with bases such as K2CO3 or Cs2CO3, enables fluoromethylation of hetero-, oxygen-, nitrogen-, and sulfur atom, respectively. (Application range: phenols, primary amines, thiocarboxylic acids, etc.)
  • Powerful tool for medicinal chemistry to access monofluoromethylated compounds easily.

2. Reaction examples


Functional group-selective monofluoromethylation of phenol

monofluoromethylation of phenol

Monofluoromethylation of primary amine group

Monofluoromethylation of primary amine group

3. Reference



  1. Miyake, Y., Wakojunyaku Jiho-Technical Report: 83(1), 6 (2015) (written in Japanese).
  2. Arnaud, J., Artiaga, M., Barth, F., Hortala, L.,Martinez, S. and Roux, P. : WO 2013/087643A1.
  3. Carroll, L., Witney, T. H. and Aboaqye, E. O.: Med. Chem., Comm., 4, 653 (2013).

4. Product List


Product Name Package Size Wako Catalog No. Grade Storage Condition
  Fluoromethyl p-Toluenesulfonate (FMTS)
1 g
for Organic Synthesis
Keep at Room Temperature.
5 g



5. Related Products



ElectrophilicFluorinatingAgent

N-Fluorobenzenesulfonimide



[133745-75-2]
069-06311
5 g
067-06312
25 g
065-06313
100 g
 

NucleophilicFluorinatingAgents

Bis(2-methoxyethyl)aminosulfur Trifluoride





[202289-38-1]
Keep at 2-10°C.
Diethylaminosulfur Trifluoride






[38078-09-0]
Keep at -20°C.
023-15801
5 g
045-31101
5 g
021-15802
25 g
043-31102
25 g


Trifluoro-methylatingAgents

N-Phenylbis-(trifluoromethanesulfonimide)

[37595-74-7]
Methyl 2,2-Difluoro-2-(fluorosulfonyl)acetate


[680-15-9]
Keep at 2-10°C.
Trimethyl(trifluoromethyl)silane




[81290-20-2]
Triethyl(trifluoromethyl)silane




[120120-26-5]
165-18691
5 g
329-79491
5 g
353-29861
5 g
201-19821
1 g
 
327-79492
25 g
351-29862
25 g
207-19823
5 g
   
209-19822
25 g
Home > Products > Chemicas > Material Chemistry > FMTS