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Near-Infrared Emission-Luciferin Analogue
Aka Lumine

 


      Wako Catalog No. 017-23691 (1 mg)
      Wako Catalog No. 013-23693 (5 mg)


INDEX

  -   Aka Lumine is ...
  -   Product Information      
  -   References    
  -   Product List     
  -   Related Products      

  PDF Leaflet (288 KB/2p)

Aka Lumine
(2-[(1E,3E)-4-(4-dimethylaminophenyl)buta-1,3-dienyl]-4,5-dihydrothiazole-4-carboxylic acid)

Aka Lumine is ...

Aka Lumine is a luciferin analog has the luminescence peak at 670 ~ 680 nm (Fig.1). The peak range is in the near-infrared (NIR) window (also known as optical window)(Fig.2). Since the adsorption of hemoglobin and water is small in the optical window, Aka Lumine is well suited to in vivo imaging 1),2).


Product Information


- C16H18N2O2S = 302.39
- Luminescence Wavelength: 670 ~ 680 nm
- Well-suited to imaging of thick tissue
- Preparation: Dissolve to DMSO (16 mg/mL) to prepare the stock solution.   After reconstitution, use it as soon as possible.


  Fig. 1 Luminescence Wavelength

     Fig. 2 Optical Window

      Fig. 3 in vivo Imaging Data of mouse
3 minutes after injection
3 min.
5 minutes after injection
5 min.
8 minutes after injection
8 min.
10 minutes after injection
10 min.
13 minutes after injection
13 min.
15 minutes after injection
15 min.
  Luciferase was expressed in mouse liver, first. Aka Lumine (1 g), which was dissolved in 60 μL of DMSO and diluted with 1 mL of PBS without calcium, was injected into the mouse (i.p.) and the luminescence imaging was observed at 3, 5, 8, 10, 13 & 15 minutes after the injection.

(Data was provided by Dr. Takeuchi, Dept. of Internal Medicine (Endocrinology & Metabolism), Univ. of Tsukuba)
Akalumine-kun


References


  1. Tromberg, B. J., Shah, N., Lanning, R., Cerussi, A., Espinosa, J., Pham, T., Svaacsand, L. and Butler, J.: "Non-Invasive In Vivo Characterization of Breast Tumors Using Photon Migration Spectroscopy" Neoplasia., 2, 26-40, (2000).
  2. Weissleder, R.: "A clearer vision for in vivo imaging", Nat. Biotechnol., 19, 316-7, (2001)

 

Product List


Product Name Package Size Wako Catalog No.
Aka Lumine
    for Biochemistry
1 mg
5 mg
017-23691
013-23693

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Leaflet (288 KB/2p)

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