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Diabetes Research
Sulfonylureas (SU)

Sulfonylurea (SU) compounds act by enhancing insulin release from the β-islet cells of the pancreas.  This is accomplished by binding a SU specific receptor site on the β-islet cell, which resullts in decreased potassium efflux across an ATP sensitive potassium channel.

INDEX

  1. Chlorpropamide
  2. Glibenclamide
  3. Gliclazide
  4. Glimepiride
  5. Tolazamide
  6. Tolbutamide
  7. Product List
  8. Related Products
  9. ⇒ LINK to Diabetes Research
                 to Metformin




1. Chlorpropamide (Wako Catalog No. 032-21482 (25 g); 034-21481 (100 g))

  • Appearance: White ~ slightly yellow, crystalline powder ~ powder
  • Assay (HPLC): 97.0+ %
  • Solubility in methanol: Clear ~ nearly clear
  • CAS No.: 94-20-2
  • C10H13ClN2O3S = 276.74

2. Glibenclamide (Wako Catalog No. 078-03881 (10 g); 076-03882 (25 g))

  • Appearance: White ~ slightly yellow, crystals ~ powder
  • Assay (Titration): 98.0+ %
  • Solubility in N, N-Dimethylformamide: clear ~ nearly clear
  • Loss on drying (105 ºC): max. 0.5 %
  • CAS No.: 10238-21-8
  • C23H28ClN3O5S = 494.00

3. Gliclazide (Wako Catalog No. 071-04731 (500 mg); 079-04732 (5 g))

  • Appearance: White ~ nearly white, crystalline powder ~ powder
  • Assay (Titration): 98.0+ %
  • Solubility in N, N-Dimethylformamide: clear ~ nearly clear
  • CAS No.: 21187-98-4
  • C15H21N3O3S = 323.41

4. Glimepiride (Wako Catalog No. 071-05691 (500 mg); 077-05693 (5 g))

  • Appearance: White ~ nearly white, crystals ~ powder
  • Assay (HPLC): 98.0+ %
  • Solubility in dimethyl sulfoxide: Clear ~ nearly clear
  • CAS No.: 93479-97-1
  • C24H34N4O5S = 490.62

5. Tolazamide (Wako Catalog No. 202-15211 (5 g); 200-15212 (25 g))

  • Appearance: White ~ slightly pale yellow, crystalline powder ~ powder
  • Assay (Titration): 96.0+ %
  • Solubility in acetone: to pass test
  • CAS No.: 1156-19-0
  • C14H21N3O3S = 311.40

6. Tolbutamide (Wako Catalog No. 209-09172 (25 g))

  • Appearance: White ~ nearly white,  crystals ~ powder
  • Assay (Titration): 99.0+ %
  • Solubility in ethanol:  Clear ~ slightly muddy
  • Heavy metals (as Pb): max. 0.001 %
  • CAS No.: 64-77-7
  • C12H18N2O3S = 270.35

7. Product List

Description Package Size Wako Catalog No. Storage Condition
25 g
100 g
in a dark place
10 g
25 g
in a dark place
500 mg
5 g
2 ~ 10 ºC
in a dark place
500 mg
5 g
2 ~ 10 ºC
in a dark place
5 g
25 g
2 ~ 10 ºC
in a dark place
25 g
~ 25 ºC
in a dark place




8. Related Product

Nateglinide (Wako Catalog No. 148-09311 (10 mg); 144-09313 (100 mg))

Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, stimulates insulin secretion by closing the ATP-sensitive K+ (KATP) channels in pancreatic β cells.
  • Appearance: White ~ slightly yellow, crystalline powder ~ powder
  • Assay (HPLC): 98.0+ %
  • Solubility in methanol: Nealy clear
  • CAS No.: 105816-04-4
  • C19H27NO3 = 317.42
     Related Product
Description Package Size Wako Catalog No. Storage Condition
Nateglinide
10 mg
100 mg
Keep at room temperature
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