Wako Catalog No. 075-05471 (10 mg)
GGsTop™ is a highly selective gamma-Glutamyl Transpeptidase (GGT) inhibitor. While acivicin [AT-125], which has been widely used as a GGT inhibitor also inhibits asparagine synthetase (GA family); GGsTop™ does not inhibit the asparagine synthetase. GGsTop™ shows 100 times higher inhibitory activity toward human GGT than that of acivicin. GGsTop™ is a very useful tool for GGT research.
High Specificity to GGT
High Inhibitory Activity to human GGT
On acute toxicity test, there is no toxicity with intravenously infused GGsTop™ (30 mg/kg). On the other hand, acivicin has severe toxicity to the CNS.
Chemical Structual Formula
Hayashida, Y., et al.: A useful approach to total analysis of RISC-associated RNA., BMC Research Notes, 2, 169 (2009).
Han, L., Hiratake, J., Kamiyama, A. and Sakata, K.: "Design, synthesis, and evaluation of gamma-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of gamma-glutamyl transpeptidase", Biochemistry, 46, 1432-47 (2007).