Cellbiology

Highly Selective gamma-Glytamyl transpeptidase (GGT) Inhibitor

GGsTop ™

Wako Catalog No. 075-05471    (10 mg)

GGsTop™ is a highly selective gamma-Glutamyl Transpeptidase (GGT) inhibitor.   While acivicin [AT-125], which has been widely used as a GGT inhibitor also inhibits asparagine synthetase (GA family); GGsTop™ does not inhibit the asparagine synthetase. GGsTop™ shows 100 times higher inhibitory activity toward human GGT than that of acivicin.   GGsTop™ is a very useful tool for GGT research.

Features

High Specificity to GGT

High Inhibitory Activity to human GGT

Low Toxicity
On acute toxicity test, there is no toxicity with intravenously infused GGsTop™ (30 mg/kg).  On the other hand, acivicin has severe toxicity to the CNS.

Chemically Stable

Chemical Structual Formula

 

ChemicalFormula

Principle

Principle

Hayashida, Y., et al.: A useful approach to total analysis of RISC-associated RNA., BMC Research Notes, 2, 169 (2009).

Reference

Han, L., Hiratake, J., Kamiyama, A. and Sakata, K.: "Design, synthesis, and evaluation of gamma-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of gamma-glutamyl transpeptidase", Biochemistry, 46, 1432-47 (2007).