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Reagents for
Animal models of human pathology for disease research

Animal models for human pathology are an important means for studying disorders such as cancer and diabetes. Administration of chemical compounds to animals such as rats and mice can lead to conditions mimicking such disorders in humans.

INDEX
  1. New products
  2. Product line up


1. New Products


Methylazoxymethanol acetate (MAM)
for animal models for schizophrenia
MAM mitigates neurogenesis in rats. Studies have associated impaired neurogenesis with disruptions of prepulse inhibition, a deficit witnessed in schizophrenia.
  • Assay: 93.8% (HPLC, first lot measurement)
  • Appearance: Liquid
  • CAS No.:592-62-1
  • C4H8N2O3 = 132.12
  • Reference: Maekawa, M., et al.: PLoS. ONE., 4, e5085 (2009).

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride (MPTP)
for animal models for Parkinson’s disease
Stored in the dopaminergic neurons of the substantia nigra, MPTP can cause neuronal death of these cells by inhibiting the enzymes necessary for mitochondria to produce ATP. This subsequently results in Parkinson’s-like symptoms.
  • Assay: min. 97.0% (HPLC)
  • Solubility: Aqueous at 10 mg/mL
  • CAS No.: 23007-85-4
  • C12H15N·HCl = 209.72



Product Name Pkg. size Wako Cat. No. Grade Storage temperature
Methylazoxymethanol Acetate (MAM)
20 mg
for Cellbiology
Keep at -20°C
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride(MPTP)
10 mg


2. Product Lineup


Pathological
model
Product Name Pkg. size Wako Cat. No. Grade Storage
temperature
Colorectal cancer
Azoxymethane
100 mg
for Cellbiology
Keep at -20°C
Breast cancer
7,12-Dimethylbenz (α) anthracene
1 g
Wako Special Grade
-
Lung cancer
Skin cancer
4-Nitroquinoline 1-Oxide
1 g
Wako Special Grade
Keep at 2-10°C
Cystitis
Protamine Sulfate, from Salmon
1 g
-
-
5 g
25 g
Colitis
Sodium Dextran Sulfate 36,000 - 50,000
10 g
-
Keep at 2-10°C
100 g
Diabetes
Streptozotocin
100 mg
for Cellbiology
Keep at -20°C
500 mg
1 g
5 g


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