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Research for Schizophrenia
Multi-acting Receptor Targeted Antipsychotics (MARTA)

Dopamine is a neurotransmitter present in the brain and is involved in mood, motivation and short memory, etc. It is hypothesized that excess dopamine activity in the mesolimbic system is the cause for positive symptoms of schizophrenia. There is also hypothesis that dominance of the serotonergic nerve system inhibiting dopaminergic nerves in the mesolimbic system due to imbalance of serotonergic nerves and dopaminergic nerves is involved in negative symptoms of schizophrenia.
However, the mechanism of schizophrenia has not been elucidated and researches on the substances that show blocking of numerous receptors of neurotransmitters such as dopamine and serotonin are ongoing.


 INDEX
      ⇒ 1. Clozapine
      ⇒ 2. Olanzapine
      ⇒ 3. Quetiapine fumarate
      ⇒ 4. Product List of MARTA
      ⇒ 5. Related products


1. Clozapine

Clozapine exhibits antagonistic action selectively on dopamine D4 receptors. It also shows antagonistic actions on serotonin 5-HT2A, 5-HT2C, 5-HT3, 5-HT6 and 5-HT7 receptors.

- Assay (HPLC): 98.0+ %
- Solubility: Soluble in ethanol
- CAS No.: 5786-21-0
- C18H19ClN4 = 326.82


2. Olanzapine
Olanzapine exhibits antagonistic actions on numerous neurotransmitter receptors such as dopamine D2, D3, D4, serotonin 5-HT2A, 2B, 2C, 5-HT6, α1-adrenaline, and histamine H1 receptors.

- Assay (HPLC): 98.0+ %
- Solubility: Soluble in acetonitrile
- CAS No.: 132539-06-1
- C17H20N4S = 312.43


3. Quetiapine fumarate
Quetiapine fumarate exhibits antagonistic actions on dopamine D2 receptor and serotonin 5HT2 receptor.
It shows higher affinity to serotonin 5-HT2 receptor than to dopamine D2 receptor. It also shows affinity to dopamine D1, serotonin 5-HT1, histamine H1, and adrenaline α1, α2 receptors.

- Assay (HPLC): 98.0+ %
- Solubility: Soluble in N,N-dimethylformamide
- CAS No.: 111974-72-2
- (C21H25N3O2S)2·C4H4O4 = 883.09


4. Product List
Code No. Product Name Package Size
031-21011 Clozapine 10 mg
037-21013 50 mg
150-03071 Olanzapine 50 mg
156-03073 500 mg
172-00691 Quetiapine Fumarate 1 g
178-00693 10 g

5. Related products
Serotonin-Dopamine Antagonists (SDA)
Code No. Product name Package Size
167-25241 Perospirone Hydrochloride Dihydrate 5 mg
163-25243 50 mg
188-02311 Risperidone 50 mg
184-02313 250 mg

Partial Dopamine receptor Agonist/Antagonist
Code No. Product name Package Size
017-23831 Aripiprazole 100 mg
013-23833 1 g

Dopamine D2 receptor blockers
Code No. Product name Package Size
033-10581 Chlorpromazine Hydrochloride 10 g
061-01751 Fluphenazine Dimaleate 1 g
084-04261 Haloperidol 1 g
080-04263 5 g
082-04262 25 g
190-12061 (±)-Sulpiride 1 g
198-12062 25 g
196-12063 100 g

Reagent for preparing schizophrenia animal model
Code No. Product name Package Size
136-16303 Methylazoxymethanol Acetate 20 mg


Listed products are for research use only. Do not administer each to human.

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