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Peptide Synthesis Specialist
PEPTIDE Institute

---Total Support from R&D to Commercial Production---

With the most advanced synthetic and analytical technologies, Peptide Institute is a global leader in peptide manufacturing, supplying reliable products to scientists across the world.
In addition, Peptide Institute is recognized as an OEM supplier for many peptide vendors.

 

Services & Specialty
Catalog Products   Almost 1000 Products Since 1963
  Biologically Active Peptides
  Enzyme Inhibitors & Substrates
  Peptide Tools
Custom Peptide Synthesis  Over 500 Different Peptides/yr
  Long Peptides and Proteins
  Modified Peptides
  Disulfide (SS-bond), Cyclic and Branched Peptides
  Enzyme Inhibitors & Substrates
  Stable Isotope-Labeled Peptides
  Glycopeptides
  Peptide Analogs for Drug Discovery
Carbohydrate Synthesis
  Mono and Oligosaccharides
  Labeled Carbohydrates
  Nucleotide Sugars
  Glycolipids
GMP Peptide
99% Successful Results in Custom Synthesis!
Synthetic Examples
  AA Length Modification
Green Fluorescent Protein 238 2 SH
Pleiotrophin (Human) 136 5 SS
Midkine (Human) 121 5 SS
PTH (Human, 1-84) 84  
[Ser(PO3H2)65]-Ubiquitin 76 Phosphorylation
FRETS-VWF73 73 Nma/Dnp Label
4-[D10]Leu-Insulin (Human) 51 3 SS/2H Label
Gla17,21,24-Osteocalcin 49 γ-Carboxyglutamate (Gla)
Amyloid β- Protein 40/42/43 Membrane Peptides
CCK-33 (Human, Porcine) 33 Sulfation
Ghrelin (Human, Rat) 28 Octanoyl-Ser

 


1. Synthetic Lipid A

No Contamination from Natural Source!
Salmonella-type Now Available

Applying most advanced synthetic technology, Salmonella-type Lipid A is now available from PEPTIDE INSTITUTE, INC.

Lipid A (E. coli)
[Compound 506, LA-15-PP]
Lipid IVa
[Compound 406, LA-14-PP, Precursor Ia]
Lipid A (Salmonella)

 

Product Lists
Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
330-0047124005-sLipid A (E. coli.) 0.1mg - 20°C
337-0048124006-sLipid Iva0.1mg - 20°C
- 24008-sLipid A (Salmonella) 0.1mg - 20°C

2. Stable Isotope-Labeled Hepcidin

Internal Standard Peptide for MS detection of Hepcidin

[13C18,15N3]-Hepcidin (Human) (Trifluoroacetate Form)

(Reported disulfide bonds between Cys7-Cys23, Cys10-Cys13, Cys11-Cys19, and Cys14-Cys22)

References

1) N. Murao, M. Ishigai, H. Yasuno, Y. Shimonaka, and Y. Aso, Rapid Commun. Mass Spectrom., 21, 4033 (2007).
2) T. Hosoki, K. Ikuta, Y. Shimonaka, Y. Sasaki, H. Yasuno, K. Sato, T. Ohtake, K. Sasaki, Y. Torimoto, K. Saito, and Y. Kohgo, Proteomics Clin. Appl., 3, 1256 (2009).

 

Product Lists
Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
337-34051 3405-v [13C18, 15N3]-Hepcidin(Human) 20μg - 20°C
339-43921 4392-s Hepcidin / LEAP-1 (Human) 0.1mg - 20°C
331-44341  4434-s Hepcidin 1 (Mouse) 0.1mg - 20°C
330-44671 4467-v Hepcidin(Rat) 50μg - 20°C

Synthesis of other animal species, different length and/or labeling are also available by custom services.

3. 2-NBDG & 2-NBDLG

Monitoring Glucose Uptake into Single, Living Cells Now Available with Antipode

2-[N-(7-Nitrobenz-2-Oxa-1,3-Diazol-4-yl)Amino]-2-Deoxy-D-Glucose [2-NBDG] is a fluorescent tracer for monitoring D-Glucose uptake into single, living cells. In addition to this widely used product, its antipodal control compound, 2-[N-(7-Nitrobenz-2-Oxa-1,3-Diazol-4-yl)Amino]-2-Deoxy-L-Glucose [2-NBDLG] is exclusively available applying newly developed synthetic method by Peptide Institute, Inc.

 

Product Lists
Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
334-00631 23002-v 2-NBDG 0.5mg - 20°C
331-0064123003-v2-NBDLG 0.5mg - 20°C

This compound is distributed through Peptide Institute, Inc. under the license of Hirosaki University Graduate School of Medicine, Tokyo University of Agriculture and Technology, and Peptide Institute, Inc.

4. Novel Fluorescent Glucose Tracer CDG

Blue Fluorescent Glucose Tracer CDG

2-NBDG has been widely utilized for monitoring D-glucose uptake through glucose transpoters (GLUTs) in a variety of mammalian cells1). By contrast, GLUT-permeable D-glucose derivatives emitting other fluorescence have been long awaited.

CDG (2-Deoxy-2-(2-oxo-2H-chromen-7-yl)amino-D-glucose) was developed as a blue fluorescent glucose tracer which attached with a coumarin2)3). Pharmacological profiles with or without inhibitors (Cytochalasin B, Phloretin, and a large amount of glucose) suggest that CDG is taken up through GLUTs in a manner similar to that reported for 2-NBDG. CDG may contribute to further understanding of the glucose study.

References

1) Nature Protocols, 2, 753 (2007). (Protocols for Measurement)
2) Org. Lett., 18, 1338 (2016). (Chem. Synthesis & Glucose Uptake in Living Cells)
3) Patent WO2015156264 A1

Product List
Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
332-0079123006-vCDG 0.5mg - 20°C

5. Antimicrobial peptides

Product Lists

Defensins

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
336-427114271-s α-Defensin 1 (Human) 0.1mg - 20°C
333-44281 4428-sα-Defensin-2 (Human)0.1mg - 20°C
333-441614416-sα-Defensin-3 (Human) 0.1mg - 20°C
330-443114431-sα-Defensin-4 (Human) 0.1mg- 20°C
336-441514415-sα-Defensin-5 (Human) 0.1mg- 20°C
331-445814458-sα-Defensin-6 (Human)0.1mg- 20°C
338-433714337-sβ-Defensin-1 (Human) 0.1mg- 20°C
335-433814338-sβ-Defensin-2 (Human)0.1mg- 20°C
333-438214382-sβ-Defensin-3 (Human)0.1mg- 20°C
337-440614406-sβ-Defensin-4 (Human)0.1mg- 20°C
338-449714497-sβ-Defensin-1 (Mouse) 0.1mg- 20°C

Other Antimicrobial Peptides

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
337-446814468-sAMP-IBP5 (Human)0.1mg - 20°C
337-449414494-vCandidalysin0.5mg - 20°C
333-323314470-vCatestatin (Human)0.5mg- 20°C
- 4454-sDermcidin- 1L (Human)0.1mg- 20°C
339-439214392-sHepcidin / LEAP-1 (Human) 0.1mg- 20°C
339-427014270-sHistatin 5 (Human) 0.1mg- 20°C
330-440514405-sLiver-Expressed Antimicrobial Peptide 2 (Human) 0.1mg- 20°C
334-444514445-sLL-37 (Human) 0.1mg- 20°C
- 4196-vMagainin 1 (Frog, Xenopus laevis) 0.5mg- 20°C
337-443214432-sPlectasin 0.1mg- 20°C

6. Synthetic EGF (Human)

Epidermal Growth Factor (EGF) EGF is a 6-kDa protein consisting of 53 amino acids residues with three intermolecular disulfide bonds.
It was originally isolated from the submaxillary glands of mice by Cohen. EGF stimulates the cell proliferation and differentiation by binding the receptor EGFR.

Product List
Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
335-449814498-sEGF (Human)0.1mg - 20°C

7. Amyloid β-Protein and Related Products

Product Lists

Amiroid β-Protein Fragments

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
330-430714307-vAmyloid β-Protein (Human, 1-40)0.5mg - 20°C
336-437914379-vAmyloid β-Protein (Human, 1-40) [HCl Form] 0.5mg - 20°C
338-434914349-vAmyloid β-Protein (Human, 1-42)0.5mg - 20°C
333-437014370-vAmyloid β-Protein (Human, 1-43)0.5mg- 20°C
334-435914359-vAmyloid β-Protein (Human, 1-16) 0.5mg- 20°C
330-448114481-vAmyloid β-Protein (Human, 1-28)0.5mg- 20°C
331-448414484-vAmyloid β-Protein (Human, 1-38)0.5mg- 20°C
333-449214492-vAmyloid β-Protein (Human, 11-40)0.5mg- 20°C
330-449314493-v[Pyr11]-Amyloid β-Protein (Human,11-40)0.5mg- 20°C
334-430914309-vAmyloid β-Protein (Human, 25-35)0.5mg- 20°C
336-436714367-v[Pyr3]-Amyloid β-Protein (Human, 3-42)0.5mg- 20°C
337-435814358-vβ-Sheet Breaker Peptide iAβ55mg- 20°C
335-00781AF-683Amyloid β-Protein (1-42, O-acyl isopeptide)2mg- 20°C

Amiroid β-Protein Control Peptides

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
332-441314413-sAmyloid β-Protein(40-1) 0.1mg- 20°C
337-442014420-sAmyloid β-Protein(42-1)0.1mg- 20°C

β-Secretase Inhibitor

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
339-437814378-vKTEEISEVN-Sta-VAEF1mg- 20°C

β-Secretase Substrate

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
334-321213212-vMOCAc-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2 1mg- 20°C

γ-Secretase Inhibitors

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
333-439414394-vL-685,458 1mg- 20°C
333-321913219-v (3,5-Difluorophenylacetyl)-Ala-Phg-OBut 5mg- 20°C

γ-Secretase Substrate

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
339-32171 3217-v Nma-Gly-Gly-Val-Val-Ile-Ala-Thr-Val-Lys(Dnp)-D-Arg-D-Arg-D-Arg-NH21mg- 20°C

Antisera

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
330-00231 14359-v Amyloid β-Protein (Human 1-16) Antiserum (Rabbit) 50μL- 20°C
330-00111 14307-v Amyloid β-Protein (Human, 1-40) Antiserum 50μL- 20°C
336-00211 14356-v Amyloid β-Protein (Human 34-40) Antiserum (Rabbit)50μL- 20°C
333-00221 14357-v Amyloid β-Protein (Human 37-42) Antiserum (Rabbit)50μL- 20°C
334-00491 14414-v Amyloid β-Protein (Human, 37-43) Antiserum50μL- 20°C

8. Ion Channel Blockers

Product Lists

Ca2+ Channel Blockers

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
332-425514255-sCalciseptine (Black mamba, Dendroaspis polylepis polylepis) (L-type Blocker) 0.1mg - 20°C
337-431014310-sCalcicludine (L-type Blocker) 0.1mg - 20°C
336-416114161-vω-Conotoxin GVIA (Marine Snail, Conus geographus) (N-type Blocker) 0.5mg - 20°C
338-428914289-vω-Conotoxin MVIIA (Cone Snail, Conus magus) (N-type Blocker) 0.5mg - 20°C
333-428414284-vω-Conotoxin SVIB (Source:Marine Snail, Conus striatus) (N-type Blocker) 0.5mg - 20°C
339-425614256-sω-Agatoxin IVA (Funnel Web Spider, Agelenopsis aperta) (P-type Blocker) 0.1mg - 20°C
339-429414294-sω-Agatoxin TK (P-type Blocker) 0.1mg - 20°C
332-428334283-vω-Conotoxin MVIIC (P/Q-type Blocker) 0.5mg - 20°C
338-436314363-sSNX-482 0.1mg - 20°C
338-437514375-sKurtoxin 0.1mg - 20°C
331-430014300-sPLTX-II0.1mg - 20°C
330-424714247-sAgelenin [Spider, Agelena opulenta] 0.1mg - 20°C

K+ Channel Blockers

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
330-423514235-sIberiotoxin (Scorpion, Buthus tamulus) 0.1mg - 20°C
330-425914259-sKaliotoxin (1-37) (Scorpion, Androctonus mauretanicus mauretanicus) 0.1mg - 20°C
338-422714227-sCharybdotoxin (Leiurus quinquestriatus var. hebraeus) 0.1mg - 20°C
336-425714257-vApamin (Honeybee, Apis mellifera)0.5mg - 20°C
333-426014260-sScyllatoxin (Scorpion, Leiurus quinquestriatus hebraeus)0.1mg - 20°C
333-425814258-vMCD-Peptide (Honeybee, Apis mellifera) 0.5mg - 20°C
334-428714287-sStichodactyla Toxin (Sea Anemone, Stichodactyla helianthus) 0.1mg - 20°C
331-429014290-sMargatoxin (MgTX) 0.1mg - 20°C
338-431314313-sTityustoxin Kalpha0.1mg - 20°C
339-433014330-sDendrotoxin 1 0.1mg - 20°C
334-443314433-sGuangxitoxin-1E 0.1mg - 20°C
335-436414364-sTertiapin 0.1mg - 20°C

Na+ Channel Blockers

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
332-421714217-vμ-Conotoxin G3B (Marine Snail, Conus geographus) 0.5mg - 20°C
334-426314263-vμ-Conotoxin GS0.5mg - 20°C
339-444014440-vμ-Conotoxin SIIIA0.5mg - 20°C
330-445514455-sHuwentoxin-IV 0.1mg - 20°C
335-445014450-sProTx-II0.1mg - 20°C

Other Blockers

Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
331-447214472-sAPETx2 0.1mg - 20°C
339-428214282-vChlorotoxin 0.5mg - 20°C
337-412614126-v α-Conotoxin G1 (Marine Snail, Conus geographus, Hydrochloride Form) 0.5mg - 20°C
334-431114311-vα-Conotoxin ImI 0.5mg- 20°C
337-414014140-vConotoxin M1 (Marine Snail, Conus magus) 0.5mg- 20°C
335-422814228-vα-Conotoxin S1
(Source : Marine Snail, Conus striatus)
0.5mg- 20°C
336-439314393-sGsMTx-4 0.1mg- 20°C
338-447314473-sMambalgin-1 0.1mg- 20°C
332-434114341-sMuscarinic Toxin 1 0.1mg- 20°C
331-441014410-sMuscarinic Toxin 3 0.1mg- 20°C
337-002414340-sMuscarinic Toxin 70.1mg- 20°C
335-442414424-sMuscarinic Toxin alpha 0.1mg- 20°C
338-440914409-sProTx-1 0.1mg- 20°C
338-443514435-sPsalmotoxin 1 0.1mg- 20°C
334-445714457-sPurotoxin-1 0.1mg- 20°C

9. The Dawson Linkers: Fmoc-Dbz/MeDbZ

For the preparation of thioester equivalents (N-Acylurea)

References

1) J.B. B-Canosa, and P.E. Dawson, Angew. Chem. Int. Ed., 47, 6851 (2008).
2) J.B. B-Canosa, B. Nardone, F. Albericio, and P.E. Dawson, J. Am. Chem. Soc., 137, 7197 (2015).

Product Lists
Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
337-233212332Fmoc-Dbz 1g - 20°C
333-233232332Fmoc-Dbz 5g - 20°C
- 2331Fmoc-MeDbz1g - 20°C
- 2331Fmoc-MeDbz5g - 20°C

10. Cellular Delivert Agent-L17E

An innovative tool, developed by Futaki (Kyoto University), for robust and highlyefficient delivery of biomacromolecules (ex. proteins or antibodies) into the cell.
L17E peptide works by preferentially rupturing endosomes to dramatically improve the cytosolic release of endosome-trapped biomacromolecules without cell toxicity.

Modifications and/or conjugations will also be available via custom services.
For more information, please visit Peptide Institute website.

References

1) M. Akishiba, T. Takeuchi, Y. Kawaguchi, K. Sakamoto, H. Yu, I. Nakase, T. Nakase, F. Madani, A. Grӓslund, S. Futaki, Nature Chemistry, 9, 751 (2017). DOI:10.1038/nchem.2779
2) WO2016/052442 A1

Product Lists
Wako Cat. CodeManufacturer CodeProduct NamePkg. SizeStorage Condition
335-340913409-vL17E Cytosolic Delivery Peptide 0.5mg - 20°C

This compound is manufactured and distributed by Peptide Institute, Inc. under the license of Kyoto University.

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