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Research for Schizophrenia
Serotonin-Dopamine Antagonists (SDA)

Dopamine is a neurotransmitter present in the brain and is involved in mood, motivation and short memory, etc. It is hypothesized that excess dopamine activity in the mesolimbic system is the cause for positive symptoms of schizophrenia. There is also hypothesis that dominance of the serotonergic nerve system inhibiting dopaminergic nerves in the mesolimbic system due to imbalance of serotonergic nerves and dopaminergic nerves is involved in negative symptoms of schizophrenia.
Serotonin-dopamine antagonists are under investigation as therapeutics for schizophrenia.


 INDEX
  1. Blonanserin
  2. Perospirone Hydrochloride Dihydrate
  3. Risperidone
  4. Product List
  5. Related products
          a. Multi-Acting-Receptor-Targeted-Antipsychotics (MALTA)
          b. Partial dopamine agonist/antagonist
          c. Dopamine D2 receptor blockers
          d. Reagent for preparing schizophrenia animal model



1. Blonanserin


This product exhibits antagonistic actions on dopamine D2 receptor and serotonin 5-HT2 receptor.


- Assay (HPLC): Not less than 98.0%
- Solubility: Soluble in acetonitrile, acetic acid, methanol, ethanol
- CAS No.: 132810-10-7
- C23H30FN3 = 367.50
Blonanserin


2. Perospirone Hydrochloride Dihydrate


This product exhibits antagonistic actions on dopamine D2 receptor and serotonin 5-HT2 receptor.


- Assay (HPLC): Not less than 98.0%
- Solubility: Soluble in methanol, ethanol, acetonitrile and water
- CAS No.: 192052-81-6
- C23H30N4O2S·HCl·2H2O = 499.07
Perospirone Hydrochloride Dihydrate



3. Risperidone
This product exhibits antagonistic actions on dopamine D2 receptor and serotonin 5-HT2A receptor.


- Assay (HPLC): 100.0% (measured value)
- Solubility: Soluble in methanol
- CAS No.: 106266-06-3
- C23H27FN4O2 = 410.48
Risperidone



4. Product List

Product Name Package Size Wako Catalog No.
Blonanserin 5 mg 022-17451
50 mg 028-17453
Perospirone Hydrochloride Dihydrate 5 mg 167-25241
50 mg 163-25243
Risperidone 50 mg 188-02311
250 mg 184-02313

QUOTATION REQUEST for SDA  
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5. Related Products
a. Multi-Acting-Receptor-Targeted-Antipsychotics (MALTA)

Product Name Package Size Wako Catalog No.
Clozapine 10 mg 031-21011
50 mg 037-21013
Olanzapine 50 mg 150-03071
500 mg 156-03073
Quetiapine Fumarate 1 g 172-00691
10 g 178-00693


b. Partial dopamine agonist/antagonist

Product Name Wako Catalog No. Package Size
Aripiprazole 100 mg 017-23831
1 g 013-23833


c. Dopamine D2 receptor blockers

Product Name Wako Catalog No. Package Size
Chlorpromazine Hydrochloride 033-10581 10 g
Fluphenazine Dimaleate 061-01751 1 g
Haloperidol 084-04261 1 g
080-04263 5 g
082-04262 25 g
(±)-Sulpiride 190-12061 1 g
198-12062 25 g
196-12063 100 g


d. Reagent for preparing schizophrenia animal model

Product Name Wako Catalog No. Package Size
Methylazoxymethanol Acetate 136-16303 20 mg

QUOTATION REQUEST for SDA  
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