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Research for depression
Serotonin-noradrenaline reuptake inhibitors (SNRI)

Serotonin is a neurotransmitter present in the brain, small intestines, platelets, etc. It is said to involve in emotional control such as lifting and suppression as well as sleep and wake, and dieting. Noradrenaline is a neurotransmitter transmitting excitement and it is distributed in sympathetic nerve terminals and central nervous system. It is secreted in the brain due to stress such as pain and fear and is said to induce the fight or flight response.
It is considered that insufficiencies of serotonin and noradrenaline in the brain induce depressive symptoms.
Serotonin-noradrenaline reuptake inhibitors (SNRIs) bind to serotonin and noradrenaline transporters, thereby inhibit the reuptake of serotonin and noradrenaline in the brain. Consequently, serotonin and noradrenaline concentrations in the synaptic gaps increase exhibiting antidepressant action. SNRIs are under investigation as therapeutics for antidepressants.


 INDEX
⇒ 1. Product Information
⇒ 2. Product List
⇒ 3. Related Products
⇒ (1) Tricyclic Antidepressants
⇒ (2) Selective Serotonin Reuptake Inhibitors (SSRI)
⇒ (3) Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs)
⇒ (4) Noradrenaline-Dopamine Reuptake Inhibitors (NDRI)
⇒ (5) Noradrenergic and specific Serotonergic Antidepressants (NaSSAs)
⇒ (6) Triazolopyridine Antidepressant -Trazodone Hydrochloride-
⇒ (7) Other Serotonin-Dopamine Receptor Antagonists
⇒ (8) Reserch for Schizophrenia
- Multi-acting Receptor Targeted Antipsychotics (MARTA)
- Serotonin-Dopamine Antagonists (SDA) -
- Aripiprazole -


1. Product Information
Duloxetine hydrochloride



- Assay (HPLC): 98.0+ %
- Solubility: Soluble in methanol and DMSO
- CAS No.: 136434-34-9
- C18H19NOS·HCl = 333.88
Milnacipran hydrochloride


- Assay (HPLC): 98.0+ %
- Solubility: Soluble in water
- CAS No.: 101152-94-7
- C15H22N2O·HCl = 282.81
Venlafaxine hydrochloride


- Assay (HPLC): 98.0+ %
- Solubility: Soluble in water
- CAS No.: 99300-78-4
- C17H27NO2·HCl = 313.86


2. Product List
Code No. Product name Package Size
041-32041 Duloxetine Hydrochloride 10 mg
047-32043 100 mg
133-17011 Milnacipran Hydrochloride 25 mg
139-17013 100 mg
227-01951 Venlafaxine Hydrochloride 500 mg

3. Related products

(1) Tricyclic antidepressants
Code No. Product name Package Size
013-12882 Amitriptyline Hydrochloride 25 g
015-23631 Amoxapine 1 g
011-23633 5 g
036-21941 Clomipramine Hydrochloride 1 g
032-21943 5 g
044-23121 Desipramine Hydrochloride 1 g
040-23123 5 g
043-32001 Doxepin Hydrochloride (mixture of isomers) 1 g
049-32003 5 g


(2) Tetracyclic antidepressants
Code No. Product name Package Size
139-17091 Maprotiline Hydrochloride 1 g
135-17093 5 g
132-16861 Mianserin Hydrochloride 50 mg
138-16863 500 mg


(3) Selective serotonin reuptake inhibitors (SSRI)
Code No. Product name Package Size
031-22231 Citalopram Hydrobromide 25 mg
037-22233 100 mg
068-04321 (±)-Fluoxetine Hydrochloride 10 mg
064-04323 50 mg
068-04326 1 g
065-05171 Fluvoxamine Maleate 5 g
061-05173 100 g
168-24431 Paroxetine Hydrochloride 100 mg
193-16191 Sertraline Hydrochloride 100 mg
199-16193 1 g


(4) Noradrenaline-dopamine reuptake inhibitors (NDRI)
Code No. Product name Package Size
028-17311 Bupropion Hydrochloride 100 mg
024-17313 1 g


(5) Noradrenergic and specific serotonergic antidepressants (NaSSAs)
Code No. Product name Package Size
134-16821 Mirtazapine 10 mg
130-16823 50 mg

(6) Triazolopyridine antidepressant
Trazodone hydrochloride

Trazodone hydrochloride is a triazolopyridine antidepressant. It acts on serotonin more selectively than noradrenaline in the inhibition of monoamine uptake and exhibits antidepressant action.
- Assay (HPLC): 98.0+ %
- Solubility: Soluble in water, ethanol, methanol and chloroform
- CAS No.: 25332.39-2
- C19H22ClN5O·HCl = 408.32

Code No. Product name Package Size
209-14964 Trazodone Hydrochloride 500 mg
205-14961 5 g

(7) Other serotonin-dopamine receptor antagonists
Wako Catalog No. Product Name
Outline
Package Size
072-05621 Granisetron Hydrochloride Serotonin receptor antagonist with high affinity to 5-HT3.
It exhibits antiemetic action.
CAS No.: 107007-99-8
10 mg
078-05623 50 mg
113-00821 Ketanserin Tartrate Serotonin receptor antagonist with high affinity to 5-HT2A
CAS No.: 83846-83-7
10 mg
119-00823 50 mg
191-15531 (+)-SCH23390 Hydrochloride Potent and selective dopamine D1 receptor antagonist and 5-HT1C/2C receptor agonist
CAS No.: 125941-87-9
10 mg
197-15533 50 mg
190-12061 (±)-Sulpiride Dopamine D2 receptor antagonist
CAS No.: 15676-16-1
1 g
198-12062 25 g
196-12063 100 g
184-00691 Reserpine Vesicular monoamine transport inhibitor
CAS No.: 50-55-5
1 g


(8) Research for schizophrenia
     ⇒ Multi-acting Receptor Targeted Antipsychotics (MARTA)
     ⇒ Serotonin-Dopamine Antagonists
     ⇒ Aripiprazole



Listed products are for research use only. Do not administer each to human.

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