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Reagents for research for depression
Tricyclic antidepressants (TCA)

Serotonin is a neurotransmitter present in the brain, small intestines, platelets, etc. It is said to involve in emotional control such as lifting and suppression as well as sleep and wake, and dieting. Noradrenaline is a neurotransmitter transmitting excitement and it is distributed in sympathetic nerve terminals and central nervous system. It is secreted in the brain due to stress such as pain and fear and is said to induce the fight or flight response.
It is considered that insufficiencies of serotonin and noradrenaline in the brain induce depressive symptoms.
Tricyclic antidepressants bind to amine transporters, thereby inhibit serotonin and noradrenaline reuptakes in the brain. Consequently, the serotonin and noradrenaline concentrations in the synaptic gaps increase exhibiting antidepressant activity. Tricyclic antidepressants also block monoamine transporters other than serotonin or noradrenaline.


 INDEX
      1. Amitriptyline hydrochloride
      2. Amoxapine
      3. Clomipramine hydrochloride
      4. Desipramine hydrochloride
      5. Doxepin hydrochloride (isomeric mixture)
      6. Product List
      7. Related products
        (1) Tetracyclic Antidepressants
        (2) Selective Serotonin Reuptake Inhibitors (SSRI)
        (3) Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs)
        (4) Noradrenaline-Dopamine Reuptake Inhibitors (NDRI)
        (5) Noradrenergic and Specific Serotonergic Antidepressants (NaSSAs)
        (6) Triazolopyridine Antidepressant
        (7) Other Serotonin-Dopamine Receptor Antagonists
        (8) Research for Schizophrenia



1. Amitriptyline hydrochloride


- Assay (Titration): 99.0+ %
- Solubility: Soluble in water, chloroform, ethanol and acetic anhydride
- CAS No.: 549-18-8
- C20H23N·HCl = 313.87
2. Amoxapine

- Assay (HPLC): 98.0+ %
- Solubility: Soluble in glacial acetic acid, chloroform and dichloromethane
- CAS No.: 14028-44-5
- C17H16ClN3O = 313.78


3. Clomipramine hydrochloride

- Assay (Titration): 98.0+ %
- Solubility: Soluble in acetic acid, water, methanol and chloroform
- CAS No.: 17321-77-6
- C19H23ClN2·HCl = 351.31
4. Desipramine hydrochloride

- Assay (Titration): 99.0+ %
- Assay (TLC): 99+ %
- Solubility: Soluble in chloroform, water and ethanol
- CAS No.: 58-28-6
- C18H22N2·HCl = 302.85



5. Doxepin hydrochloride (isomeric mixture)

- Assay (HPLC) (isomeric mixture): 98.0+ %
- Solubility: Soluble in water
- CAS No.: 1229-29-4
- C19H21NO·HCl = 315.84



6. Product List
Wako Catalog No. Product name Package Size
013-12882 Amitriptyline Hydrochloride 25 g
015-23631 Amoxapine 1 g
011-23633 5 g
036-21941 Clomipramine Hydrochloride 1 g
032-21943 5 g
044-23121 Desipramine Hydrochloride 1 g
040-23123 5g
043-32001 Doxepin Hydrochloride (mixture of isomers) 1 g
049-32003 5 g

7. Related products
(1) Tetracyclic antidepressants
Wako Catalog No. Product name Package Size
139-17091 Maprotiline Hydrochloride 1 g
135-17093 5 g
132-16861 Mianserin Hydrochloride 50 mg
138-16863 500 mg

(2) Selective serotonin reuptake inhibitors (SSRI)
Wako Catalog No. Product name Package Size
031-22231 Citalopram Hydrobromide 25 mg
037-22233 100 mg
068-04321 (±)-Fluoxetine Hydrochloride 10 mg
064-04323 50 mg
068-04326 1 g
065-05171 Fluvoxamine Maleate 5 g
061-05173 100 g
168-24431 Paroxetine Hydrochloride 100 mg
193-16191 Sertraline Hydrochloride 100 mg
199-16193 1g

(3) Serotonin-noradrenaline reuptake inhibitors (SNRIs)
Wako Catalog No. Product name Package Size
041-32041 Duloxetine Hydrochloride 10 mg
047-32043 100 mg
133-17011 Milnacipran Hydrochloride 25 mg
139-17013 100 mg
227-01951 Venlafaxine Hydrochloride 500 mg

(4) Noradrenaline-dopamine reuptake inhibitors (NDRI)
Wako Catalog No. Product name Package Size
028-17311 Bupropion Hydrochloride 100 mg
024-17313 1 g

(5) Noradrenergic and specific serotonergic antidepressants (NaSSAs)
Wako Catalog No. Product name Package Size
134-16821 Mirtazapine 10 mg
130-16823 50 mg

(6) Triazolopyridine antidepressant
      Trazodone hydrochloride
Trazodone hydrochloride is a triazolopyridine antidepressant. It acts on serotonin more selectively than noradrenaline in the inhibition of monoamine uptake and exhibits antidepressant action.
- Assay (HPLC): 98.0%
- Solubility: Soluble in water, ethanol, methanol and chloroform
- CAS No.: 25332.39-2
- C19H22ClN5O·HCl = 408.32
Wako Catalog No. Product name Package Size
209-14964 Trazodone Hydrochloride 500 mg
205-14961 5 g

(7) Other serotonin-dopamine receptor antagonists
Wako Catalog No. Product name
Outline
Package Size
072-05621 Granisetron Hydrochloride Serotonin receptor antagonist with high affinity to 5-HT3. It exhibits antiemetic action.
CAS No.: 107007-99-8
10 mg
078-05623 50 mg
113-00821 Ketanserin Tartrate Serotonin receptor antagonist with high affinity to 5-HT2A
CAS No.: 83846-83-7
10 mg
119-00823 50 mg
191-15531 (+)-SCH23390 Hydrochloride Potent and selective dopamine D1 receptor antagonist and 5-HT1C/2C receptor agonist
CAS No.: 125941-87-9
10 mg
197-15533 50 mg
190-12061 (±)-Sulpiride Dopamine D2 receptor antagonist
CAS No.: 15676-16-1
1 g
198-12062 25 g
196-12063 100 g
184-00691 Reserpine Vesicular monoamine transport inhibitor
CAS No.: 50-55-5
1 g

(8) Reagents for research for schizophrenia
Research for schizophrenia are also line up. Visit the following page.
  ⇒ Multi-acting Receptor Targeted Antipsychotics (MARTA)
  ⇒ Serotonin-Dopamine Antagonists (SDA)
  ⇒ Aripiprazole - Partial Dopamine Receptor Agonist/Antagonist


Listed products are for research use only. Do not administer each to human.
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