TIPP-703, PPAR α/δ/γ agonist
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Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor family, which is
defined as transcription factors that regulate gene expression by forming heterodimer with RXR (Retinoid X
receptor) and binding to promoter domains of the target genes.
Although the three PPAR subtypes; PPARα, PPARδ(β) and PPARγ display different tissue distribution patterns
and distinct pharmacological profiles, they all are essentially related to fatty-acid and glucose metabolism, cell
proliferation, differentiation, etc. and are focused on the association with diabetes, obesity, inflammation.
TIPP-703, which is a phenylpropionic acid-type pan agonist activates all three PPARs.
It is useful as a positive control of PPAR assay and for research of a side-effect of PPAR selective ligands, etc.
[EC50]
PPARα:    61 nmo/L
PPARδ:  120 nmol/L
PPARγ:    43 nmol/L
[Specificity]
・Assay (HPLC): 99.4%

・Solubility in methanol: to pass test
(actual measurement value of the first lot)
[References]
1. Kasuga, J., Oyama, T., Hirakawa, Y., Makishima, M., Morikawa, K., Hashimoto, Y. and Miyachi, H.:“ Improvement of the
    transactivation activity of phenylpropanoic acid-type peroxisome proliferators-activated receptor pan agonists: effect of
    introduction of fluorine at the linker part”, Bioorg. Med. Chem. Lett., 18, 4525-8 (2008).
2. Oyama, T., Toyota, K., Waku, T., Hirakawa, Y., Nagasawa, N., Kasuga, J., Hashimoto, Y., Miyachi, H. and Morikawa, K.:
    “Adaptability and selectivity of human peroxisome proliferators-activated receptor (PPAR) pan agonists revealed from
    crystal structures”, Acta Crystallogr D Biol. Crystallogr., 65, 786-95 (2009).
Description Wako Catalog No. (Pkg. Size)

TIPP-703
for Cellbiology
((S)-2-(3-((4-(1-adamantyl)benzamido)methyl)-4-propoxybenzyl)butanoic acid)
C32H41NO4=503.67

205-17881 (10 mg)
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