TIPP-703, PPAR α/δ/γ agonist
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor family, which is
defined as transcription factors that regulate gene expression by forming heterodimer with RXR (Retinoid X
receptor) and binding to promoter domains of the target genes.
Although the three PPAR subtypes; PPARα, PPARδ(β) and PPARγ display different tissue distribution patterns
and distinct pharmacological profiles, they all are essentially related to fatty-acid and glucose metabolism, cell
proliferation, differentiation, etc. and are focused on the association with diabetes, obesity, inflammation.
TIPP-703, which is a phenylpropionic acid-type pan agonist activates all three PPARs.
It is useful as a positive control of PPAR assay and for research of a side-effect of PPAR selective ligands, etc.
PPARα:    61 nmo/L
PPARδ:  120 nmol/L
PPARγ:    43 nmol/L
・Assay (HPLC): 99.4%

・Solubility in methanol: to pass test
(actual measurement value of the first lot)
1. Kasuga, J., Oyama, T., Hirakawa, Y., Makishima, M., Morikawa, K., Hashimoto, Y. and Miyachi, H.:“ Improvement of the
    transactivation activity of phenylpropanoic acid-type peroxisome proliferators-activated receptor pan agonists: effect of
    introduction of fluorine at the linker part”, Bioorg. Med. Chem. Lett., 18, 4525-8 (2008).
2. Oyama, T., Toyota, K., Waku, T., Hirakawa, Y., Nagasawa, N., Kasuga, J., Hashimoto, Y., Miyachi, H. and Morikawa, K.:
    “Adaptability and selectivity of human peroxisome proliferators-activated receptor (PPAR) pan agonists revealed from
    crystal structures”, Acta Crystallogr D Biol. Crystallogr., 65, 786-95 (2009).
Description Wako Catalog No. (Pkg. Size)

for Cellbiology
((S)-2-(3-((4-(1-adamantyl)benzamido)methyl)-4-propoxybenzyl)butanoic acid)

205-17881 (10 mg)
Listed products are intended for laboratory research use only, and not to be used for drug, food or human use.
Please visit our online catalog to search for other products from Wako ; www.e-reagent.com
This leaflet may contain products that cannot be exported to your country due to regulations.
[Related Products of TIPP-703]
Description Wako Catalog No. (Pkg. Size)
Fibrate class PPARα agonists
  Bezafibrate, 97.0+%
    CAS No. 41859-67-0; C19H20ClNO4=361.82
022-16091 (5 g); 028-16093 (100 g)
  Ciprofibrate, 98.0% (HPLC)
    CAS No. 52214-84-3; C13H14Cl2O3=289.15
033-21191 (25 mg); 039-21193 (100 mg)
  Clofibrate, 98.0% (cGC)
    CAS No. 637-07-0; ClC6H4OC(CH3)2COOC2H5=242.70
039-10603 (25 mL)
  Fenofibrate, 98.0%(HPLC)
    CAS No. 49562-28-9; C20H21ClO4=360.83
060-05361 (5 g); 068-05362 (25 g);
066-05363 (100 g)
PPARα selective agonist  <Lot No. PEE 0539: Showing activity to PPARδ and PPARγ>
  WY-14643, 99.5% (HPLC)
    CAS No. 50892-23-4, C14H14O2ClN3S=323.80
231-02371 (10 mg); 237-02373 (50 mg)
PPARα antagonist  <5-Lipoxygenase inhibitor>
  MK-886, 98.0+% (TLC)
    CAS No. 118414-82-7, C27H33ClNNaO2S=494.06
130-13001 (5 mg)
Thiazolidinedione class PPARγ agonist
  Ciglitazone, 97.0+%(HPLC)
    CAS No. 74772-77-3, C18H23NO3S=333.45, EC50=3.0 μmol/L
030-20981 (5 mg)
  Rosiglitazone, 98+% (HPLC)
    CAS No. 122320-73-4, C18H19N3O3S=357.43
186-02471 (5 mg); 182-02473 (25 mg)
  Troglitazone, 98.0% (HPLC)
    CAS No. 97322-87-7, C24H27NO5S=441.54
207-17601 (5 mg); 203-17603 (50 mg)
Irreversible PPARγ antagonist  <Cell Membrane Permeability>
  GW9662, 97.0% (HPLC)
    CAS No. 22978-25-2, C13H9N2O3Cl=276.68, IC50=3.3 nmol/L
075-05611 (5 mg); 071-05613 (25 mg)