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A mTOR inhibitor - Cancer Research
Temsirolimus (mixture of isomers)

This is a rapamycin derivative that serves as an mTOR (mammalian target of rapamycin) inhibitor. mTOR is kinase involved in the growth and increase of cancer cells, and it attracts attention as one of the targets of the cancer treatment.
It binds to FK506-binding protein-12 (FKBP-12) and inhibits the activity of mTOR, thereby suppressing cell cycle transitions and angiogenesis.



Product Summary

    Temsirolimus
  • Appearance: White - slightly pale brown, crystals - powder
  • Solubility in ethanol: to pass test
  • Assay (HPLC)(mixture of isomers): 96.8% (Initial actual value)
  • C56H87NO16=1030.29
  • CAS No.:162635-04-3

Product List

Product Name Pkg. Size Wako Cat. No. Grade Storage Condition
Temsirolimus
(mixture of isomers)
5 mg 203-20131 for Biochemistry Keep at -20°C.
25 mg 209-20133

Related Products

mTOR Inhibitors

Product Name Pkg. Size Wako Cat. No. Grade Storage Condition Summary
Compound 401

98.0+% (HPLC)

1 mg 033-21951 for Cellbiology Keep at
-20°C.
This product inhibits DNA-PK (IC50 = 0.28 μmol/L) and mTOR (IC50 = 5.3 μmol/L) reversibly and selectively. It exhibits negligible affinity to PI3K, ATM and ATR (IC50 > 100 μmol/L). It has been known to inhibit mTOR-dependent proliferation and induce apoptosis in TSC1-/- mouse embryo fibroblasts.
5 mg 039-21953
KU0063794 5 mg 115-00881 for Cellbiology Keep at
2-10°C.
A selective mTOR inhibitor.
inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases at 1000-fold higher concentrations.
PP242 5 mg 165-24441 for Cellbiology Keep at
2-10°C.
A potent and selective mTOR inhibitor (IC50=8 nmol/L (mTOR)
2 μmol/L (PI3Kα), 2.2 μmol/L (PI3Kβ), 1.3 μmol/L (PI3Kγ), 0.1 μmol/L (PI3Kδ).
Rapamycin
(mixture of isomers)
1 mg 184-02531 for Cellbiology Keep at
-20°C.
A macrolide imm unosuppressant. It is a structural analog of FK506 and binds to FKBP but does not inhibit the calcineurin activity. The rapamycin-FKBP complex inhibits IL-2 signalling by inhibiting kinase activity of mTOR. It blocks progression from the G1 to S phoase of the cell cycle.
10 mg 180-02533
50 mg 188-02534
Home > Products > Life Science > Disease Research > Temsirolimus
Home > Products > Life Science > Inhibitors > Temsirolimus