cellbiology

Anti-Cancer Effect of a Xanthone from Pericarps of Mangosteen

α-Mangostin

Wako Catalog No. 132-16241   (5 mg)

Outline

Mangostin, Garcinia mangostana L. is used as a traditional medicine in southeast Asia for inflammatory and septic ailments. The anticancer activity is induced by xanthones such as alpha-, beta-, and gamma-mangostin which are major constituents of the pericarp of mangosteen fruits. ƒ¿-Mangostin is also reported to induce apoptosis through the activation of intrinsic pathway following the down-regulation of signaling cascades, and also reported to have a cancer preventive effect.

Mangosteen

PHOTO

α-Mangostin

PHOTOCAS No. [6147-11-1]
Assay (HPLC): 97.7% (an actual measured value of the first lot)

References:
(1) Itoh, T. et al., Inhibitory effect of xanthones isolated from the pericarp of Garcinia
    mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.:
    Bioorg. Med. Chem., 16, 4500-8 (2008)
(2) kao, Y. et al., Anti-Cancer Effects of Xanthones from Pericarps of Mangosteen:
    Int. J. Mol. Sci., 9, 355-70 (2008).
(3) Shibata, M. A. et al. α-Mangostin extracted from the pericarp of the mangosteen
    (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an
    immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation:
    BMC Med., 9, 69(2011).