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Reagents for Cancer Research

Categorized by Inhibition Site

We carry reagents for basic research in cell growth, angiogenesis, and apoptosis. Newly arrived reagents for cancer research are shown below.

   INDEX

  1. DNA/RNA synthesis inhibitors
  2. Topoisomerase and telomerase inhibitors
  3. Cytoskeletal and cell-division inhibitors


   <LINKS>

   ♣ Cancer Research, categorized by functions
  1. Alkylating agents
  2. Platinum complexes
  3. Alkaloids
  4. Synthetic hormones
  5. Metabolic antagonists
  6. Antibiotics
  7. Other




  Product Name Overview Grade Pkg. Size Wako Cat.#
1. DNA/RNA synthesis inhibitors
  Aclarubicin Hydrochloride An anthracycline antibiotic. Binds to DNA and strongly inhibits nucleic acid synthesis (particularly RNA synthesis). for Biochemistry 10 mg 017-12341
  Actinomycin D An antibiotic. Binds to DNA and selectively inhibits RNA synthesis (particularly rRNA synthesis). Wako 1st Grade 1 mg 018-21264
5 mg 014-21261
25 mg 010-21263
  Bleomycin Hydrochloride An antibiotic. Inhibits DNA synthesis and shows an antitumor activity by cleaving DNA strands. for Biochemistry 10 mg 028-07801
NEW Bleomycin Sulfate for Pharmacology Research 10 mg 027-15941
50 mg 023-15943
  1,4-Butanediol Dimethanesulfonate
[Busulfan]
Suppresses cell division by inhibiting DNA synthesis and replication through alkylation of nucleic acids (mainly DNA) and other cell components. Wako 1st Grade 25 g 029-09352
  Carboplatin A platinum compound. Produces crosslinks in DNA double helix strands, and inhibits DNA synthesis and subsequent cell division. for Biochemistry 25 mg 039-16041
250 mg 035-16043
NEW Cisplatin for Pharmacology Research 200 mg 033-20091
2 g 039-20093
  Cyclophosphamide Monohydrate Suppresses cell division by inhibiting DNA synthesis and replication through alkylation of nucleic acids (mainly DNA) and other cell components. for Biochemistry 1 g 030-12953
5 g 034-12951
NEW Dacarbazine Causes DNA damage by alkylation with diazomethane produced by metabolism. for Pharmacology Research 200 mg 047-29951
1 g 043-29953
NEW Daunorubicin Hydrochloride An anthracycline antibiotic. Inhibits DNA synthesis by binding to DNA. Causes Fas-induced apoptosis in Jurkat cells. for Pharmacology Research 5 mg 043-30041
50 mg 049-30043
NEW Ifosfamide Its active metabolites, 4-hydroxy ifosfamide and aldoifosfamide, inhibit DNA synthesis of tumor cells. for Pharmacology Research 50 mg 090-05401
500 mg 096-05403
NEW Melphalan Thought to exhibit an antitumor effect by inhibiting nucleic acid synthesis through formation of intra- or interstrand crosslinks or DNA-protein crosslinks. for Pharmacology Research 100 mg 135-15251
1 g 131-15253
  Mitomycin C An antibiotic. Cleaves breakage by binding to guanine in DNA and inhibits DNA biosynthesis. for Biochemistry 10 mg 134-07911
NEW Nimustine Hydrochloride A water-soluble nitrosourea derivative. The main action mechanism is thought to be depolymerization of DNA and inhibition of DNA synthesis by DNA alkylation. for Pharmacology Research 250 mg 142-08471
1 g 148-08473
NEW Oxaliplatin A platinum compound. Produces crosslinks in DNA double helix strands, and inhibits DNA synthesis and subsequent cell division. for Pharmacology Research 5 mg 156-02691
50 mg 152-02693
  Peplomycin Sulfate A bleomycin derivative. Just like bleomycin, it is an antibiotic that exhibits an antitumor activity by inhibiting DNA synthesis and cleaving DNA strands. for Biochemistry 10 mg 169-12011
  Pirarubicin An anthracycline antibiotic. Inhibits nucleic acid synthesis and exhibits a potent antitumor activity. The structure is similar to that of doxorubicin, but the antitumor activity is more potent. for Biochemistry 25 mg 160-14741
NEW Procarbazine Hydrochloride Inhibits nucleic acid and protein synthesis by alkylating nucleic acids. for Pharmacology Research 100 mg 161-22581
1 g 167-22583
2. Topoisomerase and telomerase inhibitors
  17-AAG Causes dephosphorylation of Akt by inhibition of HSP90 followed by inactivation of Akt and apoptosis. for Cellbiology 1 mg 012-20101
  Camptothecin A reversible inhibitor of topoisomerase I. Causes DNA damage by binding to and stabilizing topoisomerase-DNA complexes. for Biochemistry 100 mg 038-18191
500 mg 034-18193
  Doxorubicin Hydrochloride
[Adriamycin Hydrochloride]
An anthracycline antibiotic. Causes DNA damage by inhibiting topoisomerase II. for Biochemistry 10 mg 040-21521
50 mg 046-21523
  Ellagic Acid Dihydrate A potent antioxidant with antimutagenic and anticarcinogenic activity. Inhibits topoisomerase I and II. for Biochemistry 5 g 056-05781
25 g 054-05782
  (-)-Epigallocatechin Gallate Thought to act on hTERT, the unit with reverse transcriptase activity. for Biochemistry 100 mg 059-05411
NEW Epirubicin Hydrochloride An anthracycline antibiotic. A stereoisomer of doxorubicin hydrochloride with inversion of the 4'-hydroxyl group. Is less toxic than doxorubicin hydrochloride. for Pharmacology Research 1 mg 058-07561
5 mg 054-07563
  Etoposide Phosphate A water-soluble derivative of etoposide. Causes DNA damage by inhibiting topoisomerase II. for Biochemistry 5 mg 058-06341
  Geldanamycin, from Streptomyces hygroscopicus Inhibits the chaperone activity of HSP90. for Biochemistry 100 μg 077-04571
  Nalidixic Acid Causes DNA damage by inhibiting DNA gyrase. for Biochemistry 5 g 148-04791
25 g 146-04792
3. Cytoskeletal and cell-division inhibitors
  Colchicine A microtubule-depolymerizing agent and cell cycle synchronizer. Inhibits tubulin polymerization at an extremely low concentration and acts as an ending factor of tubulin polymerization by binding to tubulin dimers. Wako 1st Grade 100 mg 039-03851
1 g 035-03853
  Cytochalasin B Binds to F-actin and induces depolymerization of F-actin by capping the barbed ends of actin filaments. Inhibits cytokinesis but not karyokinesis. for Biochemistry 1 mg 030-17551
5 mg 036-17553
10 mg 034-17554
  Cytochalasin D Has effects nearly identical to those of cytochalasin B, but only inhibits glucose transport induced by insulin. for Biochemistry 1 mg 037-17561
10 mg 033-17563
  Demecolcine A microtubule depolymerizing agent and cell cycle synchronizer. Has nearly the same effects as colchicine but is less toxic. for Biochemistry 5 mg 045-16963
20 mg 049-16961
  Latrunculin A Inhibits actin polymerization by binding to G-actin. for Biochemistry 1 mg 125-04363
5 mg 129-04361
  Latrunculin B for Cellbiology 1 mg 129-05101
  Mycalolide B for Biochemistry 1 μg 132-12081
  Paclitaxel Binds to β-tubulin and stabilize microtubules, and inhibits mitosis by suppressing microtubule dynamics. for Biochemistry 1 mg 169-18616
5 mg 169-18611
25 mg 165-18613
100 mg 163-18614
  Phalloidin Inhibits actin depolymerization by binding to and stabilizing F-actin. for Biochemistry 1 mg 165-15411
  Podophyllotoxin An antimitotic agent. Binds to colchicine binding site of tubulin dimers and inhibits microtubule formation competitively with colchicine. for Biochemistry 100 mg 161-20901
1 g 167-20903
  Swinholide A Stabilizes actin dimers by binding to G-actin and severs actin filaments. for Biochemistry 10 μg 197-11851
  Vinblastine Sulfate Inhibits tubulin polymerization by selectively acting on tubulin during mitosis. Can inhibit tubulin polymerization at low concentration and induces aberrant tubulin polymerization at a high concentration. for Biochemistry 10 mg 221-00751
50 mg 227-00753
NEW Vindesine Sulfate Thought to exert antitumor effect by acting on microtubule or tubulin during mitosis. for Pharmacology Research 2 mg 255-01631
10 mg 221-01633
NEW Vinorelbine Ditartrate Inhibits tubulin polymerization by selectively acting on tubulin during mitosis. for Pharmacology Research 10 mg 222-01641
50 mg 228-01643
QUOTATION REQUEST for reagents for Cancer Research

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Note

  • Listed products are intended for laboratory research use only, and not to be used for drug, food or human.
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