Cellbiology

A Fucoxanthin metabolite

Fucoxanthinol

Wako Catalog No. 067-05631   (10 mg); #063-05633   (100 mg)

Outline

Fucoxanthinol is the deacetylated form of Fucoxanthin. Fucoxanthin, a major carotenoid in edible brown algae is hydrolyzed into fucoxanthinol in the gastrointestinal tract before absorption in the intestine. Various bioactivation of Fucoxanthin is assumed to be due to that of Fucoxantinol. Furthermore, Fucoxanthinol exhibited suppressive effects on lipid accumulation during adipocyte differentiation. The suppressive effect of fucoxanthinol was stronger than that of fucoxanthin.

Physical Data

Appearance: dark red ~ dark reddish brown, crystals ~ powder

Assay (HPLC) (isomeric mixture): 94.0+ %

Solubility: Soluble in methanol, ethanol, acetonitrile, acetone, chloroform

Fucoxanthinol

PHOTO

References:
(1)Sugawara, T. et al. : "Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice", J. Nutr., 132, 946 (2002).
(2) Asai, A. et al. : "Biotransformation of fucoxanthinol into amarouciaxanthin A in mice and HepG2 cells: formation and cytotoxicity of fucoxanthin metabolites", Drug Metab. Dispos., 32, 205-11 (2004).
(3) Maeda, H. et al. : "Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells", Int. J. Mol. Med., 18, 147-52 (2006).