Endotoxin Measurement System Toxinometer® ET-6000

* The manufacturer or model name of the personal computer included in the system may be subject to change.

Toxinometer® ET-6000 is a new computer-operated model, which is exceptionally user-friendly and expandable. Depending on the number of samples to process, extension modules can be connected, allowing endotoxin testing in a wide range of fields and sample quantities. The temperature setting can be switched between 30 and 37 °C, facilitating (1 → 3)-β-D-glucan and peptidoglycan test for research projects.

Features

  • Combined with the appropriate LAL reagent, three testing techniques: turbidimetric, chromogenic and gel-clot are usable with a single system.
  • Simultaneous measurement of up to 16 samples is possible on a single module, which can be further enhanced to 512, when extension modules are connected (a total of 8 modules can be connected).
  • Systems comply with the FDA21 CFR Part 11 are also available.
  • The software provided comply with BET (USP/EP/JP).
Part 11 System
Code No. Product Name Power Source Contents
293-33509 Toxinometer® ET-6000/U Part11 Set 100 ‒ 120 ± 10 % VAC Toxinometer® ET-6000 (1 unit)
Toximaster® Part11 (5 licenses)
Personal computer (1 unit)
System validation documents
290-33519 Toxinometer® ET-6000/E Part11 Set 220 ‒ 240 ± 10 % VAC Toxinometer® ET-6000 (1 unit)
Toximaster® Part11 (5 licenses)
Personal computer (1 unit)
System validation documents
Non Part 11 System
Code No. Product Name Power Source Contents
293-33989 Toxinometer® ET-6000/U
Non-Part11 Set
100 ‒ 120 ± 10 % VAC Toxinometer® ET-6000 (1 unit)
Toximaster® (1 license)
Personal computer (1 unit)
294-33539 Toxinometer® ET-6000/E
Non-Part11 Set
220 ‒ 240 ± 10 % VAC Toxinometer® ET-6000 (1 unit)
Toximaster® (1 license)
Personal computer (1 unit)
Expansion Module (Additional Module for Part11 Set or Non-Part11 Set)
Code No. Product Name Power Source Contents
297-33529 Toxinometer® ET-6000/U
100 ‒ 120 ± 10 % VAC -
294-33539 Toxinometer® ET-6000/E
220 ‒ 240 ± 10 % VAC -
Option
Code No. Product Name Power Source Contents
295-33461 Toxinometer® ET-6000 Rack - -

Toxinometer® Measurement Principle

Toxinometer® translates the reaction of the LAL reagent with endotoxin into changes in the light intensity transmitted at 430 nm. The light intensity remains constant for a while after the start of reaction, but gradually decreases as the reaction proceeds, and stops upon completion of the reaction.
The ratio of the light intensity l(t) to the light intensity at an early stage of reaction lo is defined as R(t), and the threshold R(th) of R(t) is determined. Based on this, Toxinometer® reads the period from the start of the reaction to the point at which R(t) reaches R(th) as the gelation time Tg or the activation time Ta.

R(t) = [l(t)/lo] x 100 %

Reaction Time Course

Standard Curve

Quantification

A correlation between the endotoxin concentration and gelation time (Tg) is obtained, and the endotoxin concentration is calculated using the gelation time of a sample.

Toximaster

Exclusive software for efficient routine work and high-quality data analysis

Topics

  • LAL Basic Knowledge
  • Lysate reagent selection flowchart

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