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Tocris社
Eli Lilly社 ライセンス化合物

Tocris社では、製薬会社と試薬研究用途として取扱い契約した化合物を販売しています。
イーライリリー社のライセンス化合物をご紹介いたします。

 

コードNo. メーカーコード 品名 容量 希望納入価格
製品概要 構造式
化学名
CAS No. 分子式=分子量
保存温度 含量 溶解性
571-98791 1208/10 (2R,4R)-APDC 10mg
- 1208/50 50mg
A highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 µM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Centrally active following systemic administration in vivo. Also available as part of the Group II mGlu Receptor Tocriset™.
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate
169209-63-6 C6H10N2O4=174.16
RT ≧98%(HPLC) 100 mM in water
528-44971 0927/10 Fluoxetine hydrochloride 10mg
524-44973 0927/50 50mg
Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nM and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Deuterated analog also available.
N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
56296-78-7 C17H19ClF3NO=345.78
RT ≧99%(HPLC) 100 mM in DMSO and to 10 mM in water
- 1018/10 LY 225910 10mg
- 1018/50 50mg
Potent CCK2 receptor antagonist (IC50 = 9.3 nM for inhibition of 125I-labeled CCK-8 sulfate binding at mouse brain membranes).
2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-4-(3H)-quinazoline
133040-77-4 C27H24BrN3O2=502.41
-20℃ - 100 mM in DMSO
511-74691 1521/1 LY 233053 1mg
- 1521/10 10mg
- 1521/50 50mg
Competitive NMDA receptor antagonist (IC50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 µM. Inhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats.
(2R*,4S*)-4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylic acid
125546-04-5 C8H13N5O2=211.22
RT ≧99%(HPLC) 100 mM in water and to 100 mM in DMSO
- 1019/10 LY 235959 10mg
- 1019/50 50mg
Competitive NMDA receptor antagonist.
[3S-(3α,4aα,6β,8aα)]-Decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid)
137433-06-8 C11H20NO5P=277.26
4℃ - 100 mM in water
513-64021 3077/10 LY 272015 hydrochloride 10mg
- 3077/50 50mg
High affinity 5-HT2B receptor antagonist that displays selectivity over 5-HT2A and 5-HT2C receptors (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors respectively). Orally active.
1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
172895-15-7 C21H25ClN2O2=372.89
4℃ ≧99%(HPLC) 100 mM in DMSO and to 10 mM in ethanol
- 1524/10 LY 288513 10mg
- 1524/50 50mg
Selective CCK2 receptor antagonist (IC50 values are 16 and > 30,000 nM for CCK2 and CCK1 respectively). Displays anxiolytic and antipsychotic properties in vivo.
(4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide
147523-65-7 C22H18BrN3O2=436.3
4℃ ≧98%(HPLC) 100 mM in DMSO and to 100 mM in ethanol
510-64031 3078/10 LY 310762 hydrochloride 10mg
- 3078/50 50mg
5-HT1D-preferring receptor antagonist (EC50 = 31 nM). Displays no activity on 5-HT transport.
1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-one hydrochloride
192927-92-7 C24H28ClFN2O2=430.94
RT ≧98%(HPLC) 10 mM in water and to 100 mM in DMSO
- 3079/10 LY 334370 hydrochloride 10mg
- 3079/50 50mg
Selective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50) and 3250 nM for 5-HT1F, 5-HT1A, 5-HT4, 5-HT1E, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT2A, 5-HT7, 5-HT6 and 5-HT2C receptors respectively). Displays antimigraine effects.
4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride
199673-74-0 C21H23ClFN3O=387.88
4℃ ≧99%(HPLC) 25 mM in water with gentle warming and to 25 mM in DMSO with gentle warming
- 1209/1 LY 341495 1mg
575-76373 1209/10 10mg
579-76371 1209/50 50mg
Highly potent and selective group II metabotropic glutamate receptor antagonist (Ki/IC50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu2, mGlu3, mGlu8 , mGlu7a, mGlu1a, mGlu5a and mGlu4a receptors respectively). Readily brain penetrant and active in vivo. Disodium salt (Cat. No. 4062) also available. Also available as part of the Group II mGlu Receptor Tocriset™ Group III mGlu Receptor Tocriset™and Mixed mGlu Receptor Tocriset™.
(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid
201943-63-7 C20H19NO5=353.37
RT ≧98%(HPLC) 10 mM in DMSO with gentle warming and to 100 mM in 1.2eq. NaOH
- 2451/10 LY 344864 hydrochloride 10mg
- 2451/50 50mg
Potent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 µM for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.
N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride
1217756-94-9 C21H23ClFN3O=387.88
4℃ ≧99%(HPLC) 50 mM in water and to 100 mM in DMSO
550-75841 1237/10 LY 367385 10mg
- 1237/50 50mg
A selective mGlu1a receptor antagonist, with an IC50 value of 8.8 µM for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 µM for mGlu5a, and negligible action on group II and III receptors. Also available as part of the Group I mGlu Receptor Tocriset™.
(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid
198419-91-9 C10H11NO4=209.2
RT ≧99%(HPLC) 100 mM in 1.1eq. NaOH
510-22271 2453/10 LY 379268 10mg
- 2453/50 50mg
Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. Caged LY 379268 is also available (Cat. No. 3332).
(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
191471-52-0 C7H9NO5=187.15
4℃ ≧99%(HPLC) 20 mM in water and to 100 mM in 1eq. NaOH
- 2452/1 LY 2183240 1mg
- 2452/10 10mg
Novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.
5-[(1,1'-Biphenyl]-4-yl)methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide
874902-19-9 C17H17N5O=307.35
4℃ ≧98%(HPLC) 100 mM in DMSO and to 50 mM in ethanol with gentle warming
- 1519/10 Quinelorane hydrochloride 10mg
Dopamine D2 and D3 receptor agonist; Ki values are 5.7 and 3.4 nM respectively.
(5aR,9aR)-5,5a,6,7,8,9,9a,10-Octahydro-6-propylpyrido[2,3-g]quinazolin-2-amine dihydrochloride
97548-97-5 C14H24Cl2N4=319.27
RT ≧99%(HPLC) 25 mM in water
553-75831 1061/10 (-)-Quinpirole hydrochloride 10mg
- 1061/50 50mg
Selective dopamine D2 receptor agonist (Ki values are 4.8, 〜24, 〜30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).
(4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride
85798-08-9 C13H22ClN3=255.79
-20℃ ≧98%(HPLC) 100 mM in water and to 25 mM in DMSO

Tocris社の製品は、製造バッチによって水和の程度や塩が変更される場合があり、分子式・分子量がカタログ・ウェブと異なることがございます。正式な分子式は現品バイアルのラベルと添付データシートでご確認下さい。

 

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富士フイルム和光純薬工業

本社〒540-8605大阪市中央区道修町三丁目1番2号       TEL 06-6203-3741(代表)
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