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Tocris社
Merck社 ライセンス化合物

Tocris社では、製薬会社と試薬研究用途として取扱い契約した化合物を販売しています。
メルク社のライセンス化合物をご紹介いたします。

 

コードNo. メーカーコード 品名 容量 希望納入価格
製品概要 構造式
化学名
CAS No. 分子式=分子量
保存温度 含量 溶解性
515-83021 3235/10 CDPPB 10mg
511-83023 3235/50 50mg
Brain penetrant, selective positive allosteric modulator at the mGlu5 receptor (EC50 values are 10 and 20 nM for human and rat receptors respectively). Antipsychotic; reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.
3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
781652-57-1 C23H16N4O=364.4
4℃ ≧98%(HPLC) 75 mM in DMSO
- 0281/10 (R)-(+)-HA-966 10mg
Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier. Available as part of the NMDA Receptor - Glycine Site Tocriset™. S-enantiomer also available.
(R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one
123931-04-4 C4H8N2O2=116.12
RT ≧98%(HPLC) 100 mM in water
538-51241 0742/10 L-689,560 10mg
- 0742/50 50mg
Very potent antagonist at the glycine-NMDA site. Also available as part of the NMDA Receptor - Glycine Site Tocriset™.
trans-2-Carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
139051-78-8 C17H15Cl2N3O3=380.23
RT ≧99%(HPLC) 25 mM in DMSO and to 100 mM in ethanol
- 0681/10 L-690,330 10mg
- 0681/50 50mg
A potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.
[1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
142523-38-4 C8H12O8P2=298.13
RT - 100 mM in water with gentle warming
- 0682/5 L-690,488 5mg
Cell-permeable prodrug of the potent inositol monophosphatase inhibitor L-690,330 (Cat. No. 0681); penetrates cells more effectively than its metabolite.
1-[(4-Hydroxyphenoxy)ethylidene]bis[phosphinylidyne]bis(oxymethylene)]-2,2-dimethylpropanoate
142523-14-6 C32H52O16P2=754.7
-80℃ ≧98%(HPLC) 100 mM in ethanol and to 100 mM in DMSO
531-43041 0426/10 L-693,403 maleate 10mg
- 0426/50 50mg
High affinity sigma ligand with excellent selectivity over the dopamine D2 receptor.
N-1'-Benzyl-3,4-dihydrospiro[1H-indene-1,4'-piperidine] maleate
207455-21-8 C24H27NO4=393.48
-20℃ - 100 mM in DMSO
531-50991 0781/10 L-694,247 10mg
- 0781/50 50mg
Selective and extremely potent 5-HT1D receptor agonist.
2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine
137403-12-4 C20H21N5O3S=411.48
4℃ ≧98%(HPLC) 100 mM in DMSO
536-43111 0705/10 L-701,252 10mg
- 0705/50 50mg
An antagonist at the glycine-NMDA site (IC50 = 420 nM). Also a potent systemic anticonvulsant.
7-Chloro-3-(cyclopropylcarbonyl)-4-hydroxy-2(1H)-quinolinone
151057-13-5 C13H10ClNO3=263.68
4℃ ≧99%(HPLC) 50 mM in DMSO
533-51171 0907/10 L-701,324 10mg
- 0907/50 50mg
An orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
142326-59-8 C21H14ClNO3=363.8
RT ≧99%(HPLC) 100 mM in DMSO
504-38241 0868/10 L-732,138 10mg
- 0868/50 50mg
Potent and highly selective competitive tachykinin NK1 receptor antagonist (IC50 = 2.3 nM).
N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester
148451-96-1 C22H18F6N2O3=472.39
RT ≧98%(HPLC) 100 mM in ethanol and to 100 mM in DMSO
- 1145/10 L-733,060 hydrochloride 10mg
- 1145/50 50mg
Potent NK1 antagonist (Ki values are 0.08, 0.2 and 93.13 nM for gerbil, human and rat receptors, respectively). Produces anxiolytic-like effects in the gerbil elevated plus-maze. Exhibits antitumor activity in vitro. Also decreases HER2 activity and tumor growth in mice bearing HER2+ or EGFR+ breast tumors. Orally bioavailable and brain penetrant.
(2S,3S)-3-[[3,5-bis(Trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine hydrochloride
148687-76-7 C20H20ClF6NO=439.83
RT ≧99%(HPLC) 50 mM in water with gentle warming
509-38291 1003/10 L-741,626 10mg
- 1003/50 50mg
A potent D2 dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D2, D3 and D4 receptors respectively. Centrally active following systemic administration in vivo.
3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole
81226-60-0 C20H21ClN2O=340.85
RT ≧98%(HPLC) 100 mM in DMSO and to 100 mM in ethanol
576-98741 1004/10 L-741,742 hydrochloride 10mg
- 1004/50 50mg
A potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride
874882-93-6 C23H26Cl2N2O=417.38
RT ≧98%(HPLC) 10 mM in DMSO
518-81791 2640/10 L-703,664 succinate 10mg
- 2640/50 50mg
5-HT1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50 values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D, 5-HT1A, 5-HT2A and 5-HT3 respectively) and other receptors (pIC50 < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors).
N,N-Dimethyl-5-[(5-methyl-1,1-dioxodo-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indole-3-ethanamine succinate
144776-01-2 C20H30N4O6S=454.54
4℃ ≧99%(HPLC) 50 mM in water and to 100 mM in DMSO
503-37851 1002/10 L-745,870 trihydrochloride 10mg
509-37853 1002/50 50mg
A highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and > 1000-fold selectivity over 5-HT2, D1 and D5 receptors.
3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
866021-03-6 C18H22Cl4N4=436.21
4℃ ≧99%(HPLC) 100 mM in water
512-96461 3250/10 L-838,417 10mg
- 3250/50 50mg
Subtype-selective GABAA receptor partial agonist. Selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo.
3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
286456-42-6 C19H19F2N7O=399.4
4℃ ≧98%(HPLC) 50 mM in DMSO and to 20 mM in ethanol with sonication
516-96481 3817/10 MRK 016 10mg
- 3817/50 50mg
GABAA receptor inverse agonist selective for the α5-subtype (EC50 = 3 nM). Exhibits affinity at benzodiazepine binding site of recombinant human GABAA receptors (Ki values are 0.77 nM, 0.83 nM, 0.85 nM and 1.4 nM for α3-, α1-, α2-, and α5-containing respectively). Increases long-term potentiation (LTP) in mouse hippocampal slices. Exhibits no anxiogenic or proconvulsant activity.
3-(1,1-Dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-pyrazolo[1,5-d][1,2,4]triazine
342652-67-9 C17H20N8O2=368.39
4℃ ≧98%(HPLC) 100 mM in DMSO and to 10 mM in ethanol
516-96501 4000/10 MRK 560 10mg
- 4000/50 50mg
γ-secretase inhibitor; inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Reduces levels of Aβ in the brain (inhibits Aβ40 and Aβ42 in SH-SY5Y neuroblastoma cells with an IC50 of 0.65 nM); attenuates plaque deposition. Orally bioavailable.
N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
677772-84-8 C19H17ClF5NO4S2=517.92
4℃ ≧99%(HPLC) 100 mM in DMSO and to 50 mM in ethanol
518-83011 2921/10 MTEP hydrochloride 10mg
- 2921/50 50mg
Potent, selective and non-competitive mGlu5 antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki= 16 nM). Displays anxiolytic activity in vivo and is orally active.
3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
1186195-60-7 C11H9ClN2S=236.72
-20℃ ≧99%(HPLC) 100 mM in water and to 100 mM in DMSO
513-96491 3818/10 TCS 1102 10mg
- 3818/50 50mg
Potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo and blocks orexin-A (Cat.No.1455) mediated increases in feeding behaviour. Brain penetrant.
N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide
916141-36-1 C27H26N4O2S=470.59
RT ≧98%(HPLC) 100 mM in DMSO and to 100 mM in ethanol

Tocris社の製品は、製造バッチによって水和の程度や塩が変更される場合があり、分子式・分子量がカタログ・ウェブと異なることがございます。正式な分子式は現品バイアルのラベルと添付データシートでご確認下さい。

 

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富士フイルム和光純薬工業

本社〒540-8605大阪市中央区道修町三丁目1番2号       TEL 06-6203-3741(代表)
東京本店〒103-0023東京都中央区日本橋本町二丁目4番1号 TEL 03-3270-8571(代表)
●九州営業所 092-622-1005(代) ●中国営業所 082-285-6381(代) ●東海営業所 052-772-0788(代)
●藤沢営業所 0466-29-0351(代) ●筑波営業所 0298-58-2278(代) ●東北営業所 022-222-3072(代)
●北海道営業所 011-271-0285(代)
E-mail: ffwk-labchem-tec@fujifilm.com URL: http://www.wako-chem.co.jp
フリーダイヤル: 0120-052-099 フリーファックス: 0120-052-806