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 MC
OsO4(synthesis of diol) |
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Specialty Chemical home >MCOsO4(synthesis
of diol)
Wako is contracting for custom manufacturing
of chiral diols with the use of Osmium(VIII) oxide, Microencapsulated
industrially.
- Wako will contract for custom manufacturing with the use of
Osmium(VIII)oxide, Microencapsulated industrially.
- When Osmium(VIII)oxide, Microencapsulated is used,
OsO4 remaining in products is fewer when compared to the use
of only OsO4. We can report actual measurement value of OsO4
remaining in products
- We will design Osmium(VIII)oxide, Microencapsulated
optimized for reaction system.
- Osmium(VIII)oxide, Microencapsulated utilized chiral
ligand has possibility of asymmetrical reaction.
dihydroxylation utilized Osmium(VIII)oxide, Microencapsulated(MC.OsO4)
a: NMO=N-methylmorpholine-N oxide ( reoxidizing reagent )
b: reaction time :3h
reaction in bilayer system utilized Osmium(VIII)oxide,
PEM-Microencapsulated(PEM-MC.OsO4)
PEM-MC.OsO4 utilized hydrophilic polymer as
catalyst support is reoxidized in bilayer system by potassium
ferricyanide as reoxidant. It can apply to asymmetrical reaction
using chiral ligand.
| run |
yield(%) |
ee(%) |
| 1 |
85 |
78 |
| 2 |
66 |
78 |
| 3 |
84 |
78 |
References
- S.Kobayashi, M.Endo, S.Nagayama: J. Org. Chem., 63, 6094(1998)
- S.Kobayashi, T.Ishide, R.Akiyama: Org. Lett.., 3, 2649(2001)
Click here for further
information of custom manufacturing.
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Outline
of custom manufacturing (custom synthesis)