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 Biodegradable
Polymers |
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Specialty Chemicals Home
> biodegradable Polymers(PLA. PLGA)
PLA(poly lactic acid) and PLGA ( copoly lactic
acid/glycolic acid) are superior in biocompatibility and biodegradability,
and are useful materials as base material for sustained-release
formulation. We have been providing PLA and PLGA not only as laboratory
reagents but also produced under GMP controlled condition
- No contamination from catalysts such as heavy metals because
of uncatalyzed reaction.
- We are able to provide an injectable formulation grade produced
on industrial scale as required by
the customers.
- Our PLA and PLGA of general grade are for laboratory use.
| product code |
product name |
composition rate |
weight-average molecular weight |
inherent viscosity
(dl/g) |
| DL-lactic acid |
glycollic acid |
|
825-11806
|
PLA-0005
|
100 |
0 |
5,000 |
0.085-0.099
|
|
822-11816
|
PLA-0010
|
100 |
0 |
10,000 |
0.118-0.137
|
|
829-11826
|
PLA-0015
|
100 |
0 |
15,000 |
0.147-0.177
|
|
826-11836
|
PLA-0020
|
100 |
0 |
20,000 |
0.177-0.216
|
|
829-11946
|
PLGA-7505
|
75 |
25 |
5,000 |
0.082-0.098
|
|
826-11956
|
PLGA-7510
|
75 |
25 |
10,000 |
0.119-0.140
|
|
823-11966
|
PLGA-7515
|
75 |
25 |
15,000 |
0.152-0.185
|
|
820-11976
|
PLGA-7520
|
75 |
25 |
20,000 |
0.186-0.230
|
|
821-11906
|
PLGA-5005
|
50 |
50 |
5,000 |
0.088-0.102
|
|
828-11916
|
PLGA-5010
|
50 |
50 |
10,000 |
0.122-0.143
|
|
825-11926
|
PLGA-5015
|
50 |
50 |
15,000 |
0.154-0.186
|
|
822-11936
|
PLGA-5020
|
50 |
50 |
20,000 |
0.187-0.229
|
Product weight is only 25 g. Prohibit any purpose without
research use or test because these products are not control under
GMP or GLP.
Please contact us separately in case where the purpose is application
for medical products.
Degradability of PLGA within an organism changes
according to monomer composition. When monomer composition rate
is 50/50, the degradability kinetics is the fastest and the degradability
kinetics is slowed to such an extent that monomer composition
rate comes free from 50/50.(Fig. 1.)
As shown on Fig. 2, releasing capacity of microencapsulated
TRH (thyrotropin-releasing hormone) tends to be bigger in the
order corresponding to 50/50>75/25>100/0 in rate of lactic acid
and glycol. The releasing capacity is associated with degradability
of PLGA, as it has been said earlier.
Fig. 3 shows that release rate from microspheres
is slowed to such an extent that PLGA Mw. is higher.
When drugs using PLGA are designed, it is
important to chooce most suitable composition of PLGA and its
Mw. When PLGA is applied to controled release formulation, it
is necessary to screen various PLGAs in vitro or vivo because
the change of drug release depends on drug itself.
Fig. 1. Half life of various of lactic acid and glycolic acid as copolymers implanted in rat tissue.
Fig. 2. Release profiles of TRH from PLGA microspheres with different copolymer ratios of PLGA.
Fig. 3. Effect of molecular weight of PLGA75/25 on release profiles of TRH microspheres.
References
- R.Miller, J. M. Brady, and D. Cutright, J.
Biome. Mater. Res., 11, 711 (1977).
- T. Heya, H. Okada, Y. Ogawa, and H. Toguchi, Int.
J. Pharm., 72, 199-205 (1991)
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Aminothiazole
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